预防小儿包皮手术术后躁动右美托咪定最佳剂量研究.docVIP

预防小儿包皮手术术后躁动右美托咪定最佳剂量研究 　　【摘要】 目的：探究右美托咪定?A防小儿包皮手术术后躁动的最佳使用剂量。方法：选取2016年7月-2017年7月本院收治的择期小儿包皮环切术患儿180例。按照随机数字表法将其分为A、B、C、D、E、F（对照组）组，各30例。A组单次静脉注射右美托咪定0.2 μg/kg，B组单次静脉注射右美托咪定0.3 μg/kg，C组单次静脉注射右美托咪定0.4 μg/kg，D组单次静脉注射右美托咪定0.5 μg/kg，E组单次静脉注射右美托咪定0.6 μg/kg，F组注射氯化钠注射液。观察各组用药前后HR、RR及SpO2水平、进入术后恢复室（PACU）后各时间点的躁动情况、回到病房后各时间点的疼痛和镇静情况。结果：用药后，A、F组HR均高于用药前及B～E组（P0.05），B～E组均较用药前下降（P0.05）；进入PACU后20、25、30 min，A组躁动评分均显著高于B～E组，比较差异有统计学意义（P0.05）；回到病房2、6 h，A组疼痛评分均高于B～E组（P0.05）；回到病房1、2 h，F组镇静评分均低于A～E组，且A组镇静评分均低于B～E组，比较差异有统计学意义（P0.05）。结论：0.3～0.6 μg/kg剂量的右美托咪定可有效对抗氯胺酮引起的心率加快，在预防小儿包皮手术术后躁动及镇痛镇静中具有较好的效果。 　　【关键词】 右美托咪定； 包皮手术； 躁动； 最佳剂量 　　Study on Optimal Dosage of Dexmedetomidine for Preventing Postoperative Agitation in Pediatric Circumcision/LIANG Zhantao，TAN Jingdi.//Medical Innovation of China，2018，15（08）：004-008 　　【Abstract】 Objective：To explore the optimal dosage of Dexmedetomidine for preventing postoperative agitation in pediatric circumcision.Method：A total of 180 patients with selective circumcision from July 2016 to July 2017 in our hospital were selected，according to the random digital table method，they were divided into group A，B，C，D，E，F（the control group），30 cases in each group.Group A received a single intravenous injection of Dexmedetomidine 0.2 μg/kg，group B received a single intravenous injection of Dexmedetomidine 0.3 μg/kg， 　　group C received a single intravenous injection of Dexmedetomidine 0.4 μg/kg，group D received a single intravenous injection of Dexmedetomidine 0.5μg/kg，group E received a single intravenous Dexmedetomidine 0.6 μg/kg，group F was injected with Sodium Chloride Injection.The levels of HR，RR and SpO2 before and after the medication，the agitation of each time point after PACU，and the pain and sedation at each time point after returning to the ward in each group were compared.Result：After medication，HR in group A and F were higher than those of before medication and group B-E（P 　　【Key words】 Dexmedetomidine； Circumcision； Agitation； Optimal dosage