颈动脉狭窄支架置入与认知功能相关性研究.docVIP

颈动脉狭窄支架置入与认知功能相关性研究 　　【摘要】 目的：研究颈动脉狭窄患者支架置入术（CAS）与认知功能的相关性。方法：纳入2014年 　　10月1日-2016年4月10日本院住院的颈动脉狭窄患者36例，均经DSA检查明确诊断，狭窄程度50%，对患者进行一般情况评估。23例患者行CAS治疗（CAS组），13例患者给予药物保守治疗（对照组）。所有患者在治疗前，治疗后6、12个月进行MoCA评分。结果：CAS组患者治疗后6、12个月MoCA量表总分及视空间与执行功能、注意力、延迟回忆力较治疗前均明显改善（P0.05）。治疗组与对照组比较，治疗后6个月认知功能显著改善，主要体现为视空间与执行功能、延迟回忆力的改善（P50%的颈动脉狭窄患者，颈动脉支架置入术能改善患者的认知功能，尤其是视空间与执行功能、注意力、延迟回忆力。 　　【关键词】 颈动脉狭窄； 颈动脉支架置入术； 认知功能 　　【Abstract】 Objective：To study the correlation between carotid artery stenting（CAS） and cognitive function in patients with carotid artery stenosis.Method：A total of 36 cases with carotid artery stenosis in our hospital from October 1，2014 to April 10，2016 were included.All patients were diagnosed by DSA，and the degree of stenosis was greater than 50%.The general state of health of all subjects were estimated.23 cases were performed CAS（CAS group） and 13 cases just accepted drug treatment（the control group）.The cognitive functions of all patients were estimated with Montreal Cognition Assessment（MoCA） before treatment，6 and 12 months after treatment.Result：The total score of MoCA scale，visual space and executive function，attention and delayed recall ability of CAS group after operation were significantly improved than those of before operation（P0.05）.Compared with the control group，the total score of MoCA scale，visual space and executive function and delayed recall ability of CAS group were improved significantly after 6 months of treatment（P0.05）.The total score of MOCA scale，Visual space and executive function，naming ability，attention and delayed recall ability of CAS group improved significantly compared with the control group after 12 months of treatment（P0.05）.Conclusion：For the patients with carotid artery stenosis which greater than 50%，CAS may improve the cognitive function of the patients，especially the visual space and executive function，attention and delayed recal ability. 　　【Key words】 Carotid artery stenosis； Carotid artery stenting； Cognitive function 　　Fir