调理脾胃针法对糖尿病胃轻瘫患者脑肠肽的调节作用及疗效观察.docVIP

调理脾胃针法对糖尿病胃轻瘫患者脑肠肽的调节作用及疗效观察 　　[摘要] 目的 探讨调理脾胃针法对糖尿病胃轻瘫（DGP）患者脑肠肽的调节作用及疗效。 方法 选择72例DGP患者随机分为联合组和对照组。两组患者均予控制饮食、适量运动和控制血糖等基础治疗。两组患者均予莫沙比利片5 mg/次，3次/d，口服；联合组患者配合调理脾胃针法针刺治疗，两组均连用8周。比较两组患者治疗前与治疗8周后血清VIP和NO指标的变化情况，并进行临床疗效评估。结果 治疗8周后，两组患者血清VIP和NO指标与治疗前比较明显下降（P0.05或P0.01），且联合组治疗后VIP和NO指标明显低于对照组（P0.05）；同时联合组和对照组治疗的总有效率分别为94.44%和77.78%，联合组明显高于对照组（χ2=4.18，P0.05）。 结论 调理脾胃针法联合西药莫沙比利治疗DGP疗效确切，作用机制可能与其能降低血清VIP和NO指标水平、纠正脑肠肽分泌紊乱、促进胃肠动力密切相关。 　　[关键词] 糖尿病胃轻瘫；调理脾胃针法；血管活性肠肽；一氧化氮 　　[中图分类号] R246.1 [文献标识码] B [文章编号] 1673-9701（2017）06-0123-03 　　[Abstract] Objective To investigate the regulation and curative effect of regulating spleen-stomach needling on brain-gut peptide in patients with diabetic gastroparesis（DGP）. Methods 72 patients with DGP were randomly divided into combination group and control group. Both groups were given basic treatment including controlling diet， moderate exercise and controlling blood glucose.Two groups of patients were treated with moxabiride tablets 5 mg each time， 3 times/d， oral， and the combined group was also given treatment of regulating spleen-stomach needling. The treatment in the two groups both lasted for 8 weeks. The serum VIP and NO indexes were compared between the two groups before and after 8 weeks of treatment， and the clinical curative effect was evaluated. Results After 8 weeks of treatment， the levels of serum VIP and NO in the two groups significantly decreased compared with those before treatment（P0.05 or P0.01）， and the VIP and NO indexes were significantly lower in the combined group than those in the control group（P0.05）. The total effective rates were 94.44% and 77.78% in the combined group and the control group， respectively， and the total effective rate in combined group was significantly higher than that in the control group（χ2=4.18， P0.05）. Conclusion Regulating spleen-stomach needling method combined with western medicine moxapril in the treatment of DGP is effective， and the mechanism may be closely related to its ability to re