高黏度骨水泥经皮椎体成形术联合仙灵骨葆胶囊治疗骨质疏松性椎体压缩性骨折临床研究.docVIP

高黏度骨水泥经皮椎体成形术联合仙灵骨葆胶囊治疗骨质疏松性椎体压缩性骨折临床研究 　　[摘要] 目的 探讨高黏度骨水泥经皮椎体成形术联合仙灵骨葆胶囊治疗骨质疏松性椎体压缩骨折的效果。 方法 选择2014年8月～2015年12月于泰山医学院附属聊城市第二人民医院骨科治疗的骨质疏松性椎体压缩性骨折患者60例，随机分成两组，各30例。治疗组在PVP术后给予仙灵骨葆胶囊+钙片，连续使用6周为1个疗程，共2个疗程；对照组PVP术后单纯口服钙片。分别在术前、术后1周、术后1个月、术后3个月以及术后6个月时评估视觉模拟评分法（VAS）评分、Oswestry功能障碍指数（ODI）评分、骨密度（BMD）、不良反应情况等指标。 结果 两组中术后VSA评分、ODI评分、BMD值均较术前明显改善（P 0.05）。 结论 高黏度骨水泥椎体成形术结合仙灵骨葆胶囊治疗骨质疏松性椎体压缩性骨折取得了良好效果，能显著缓解患者疼痛，提高生活质量，改善骨质疏松，值得临床推广。 　　[关键词] 高黏度骨水泥；经皮椎体成形术；仙灵骨葆胶囊；骨质疏松；椎体压缩性骨折 　　[中图分类号] R683 [文献标识码] A [文章编号] 1673-7210（2016）08（c）-0093-04 　　[Abstract] Objective To observe the curative effect of treatment of osteoporotic vertebral compression fractures （OVCF） by combing high-viscosity cements percutaneous vertebroplasty（PVP） and Xianlinggubao Capsules. Methods From August 2014 to December 2015， 60 patients with OVCF treated in Department of Orthopaedics， the Second People′s Hospital of Liaocheng City Affiliated to Taishan Medical University were selected. They were randomly divided into the treatment group and control group， each group had 30 cases. The patients in the treatment group were treated with Xianlinggubao Capsules and D-CAL after PVP operation. Six weeks taken as a course of treatment， and two courses were applied. The patients in the control group were treated with D-CAL only after PVP. The clinical efficacy of the two groups were assessed with the visual analogue pain score （VAS）， Oswestry disability index （ODI） and bone mineral density （BMD） before the operation and after the operation at one week， one month， three months， and six months respectively， also the adverse reaction was evaluated. Results Compared with before operation， the postoperation VAS scores， ODI score， and BMD in the two groups improved significantly （P 0.05）. Conclusion High-viscosity cements PVP combined with Xianlinggubao Capsules in the treatment of patients with OVCF has excellent effect， it can effectively relieve the pain of the patients， improve their life quality and reduce osteoporos