鼻腔NKT细胞淋巴瘤疗效及预后分析.docVIP

鼻腔NKT细胞淋巴瘤疗效及预后分析 　　[摘要] 目的 分析鼻腔NK/T细胞淋巴瘤的疗效及预后因素。方法 分析1996年9月～2005年9月本院收治的60例Ⅰ/Ⅱ期鼻腔NK/T细胞淋巴瘤资料。单因素分析采用Kaplan-Meier法,多因素分析运用Cox比例风险模型。结果 全组5年总生存率(OS)和无病生存率(DFS)分别为56.4%与38.6%。达CR与未达CR的5年OS率分别为60.4%及16.0%(P0.05),5年DFS分别为57.0%及51.4%(P0.05)。放疗后化疗和化疗后放疗的5年OS率及DFS率分别为59.2%及52.6%,和53.6%及47.5%,无统计学意义。多因素分析显示,B症状、CR率、超腔为独立预后因素。结论 单纯化疗在早期鼻腔NK/T细胞淋巴瘤疗效差。B症状,超腔,CR率是判断预后的指标。 　　[关键词] NK/T细胞淋巴瘤;放射治疗;化学治疗;预后 　　[中图分类号] R739.62[文献标识码] A [文章编号] 1673-9701(2010)04-06-03 　　 　　Prognostic Factors and Curative Efficacy of Nasal NK/T-cell Lymphoma 　　LUO YangkunTAN YanFU BinyuWEN Hao 　　Radiation Therapy Center,Sichuan Provincial Tumor Hospital,Chengdu 610041,China 　　 　　[Abstract] Objective To analyze the curative efficacy and prognostic factors in 60 cases of primary nasal NK/T-cell lymphoma. Methods From Sept.1996 to Sept.2005, 60 cases of nasal NK/T-cell lymphoma were diagnosed pathologically. Data from these patients were reviewed. Kaplan-Meier methods were applied in single-factor analysis,and the Cox regression model was applied in multivariate analysis. Results The 5-year overall survival(OS)rate and disease free survival(DFS)rate for all patients were 56.4% and 38.6%. The 5-year OS rate for CR and no-CR patients was 60.4% and 16.0%(P0.05). The 5-year OS rate and DFS rate of chemotherapy alone group and combined therapy group were 18.8% and 15.2%,56.7% and 51.4%,respectively. The 5-year OS rate and DFS rate were 59.2% and 52.6% for radiotherapy followed by chemotherapy,and 53.6% and 47.5% for chemotherapy followed by radiotherapy. The COX regression showed that B symptoms,local tumor invasion out of the nasal cavity andCR rate were independent prognostic factors. Conclusion NK/T-cell lymphoma shows low chemotherapy sensitivity. B symptoms,local tumor invasion out of the nasal cavity and CR rate are independent prognostic factors. 　　[Key words] Nasal NK/T-cell lymphoma;Radiotherapy;Chemotherapy;Prognosis 　　NK/T细胞淋巴瘤是恶性淋巴瘤中的少见特殊类型,鼻腔NK/T细胞淋巴瘤是除韦氏环外最常见的结外非霍奇金淋巴瘤,占全部恶性淋巴瘤的2%～10