动态观察短期胰岛素强化治疗对新诊2型糖尿病患者胰岛β细胞功能影响-内分泌学专业论文.docxVIP

Oral glucose tolerance test(OGTT) and C-peptide release test were performed respectively. C-p/PGAUC、Homa?、HomaIR、FPG、2hPG were calculated, and the result of blood lipid were compared before and after CSII．In addition，the thirty patients were divided into three sub- groups，respectively from age(=60yrs vs 60yrs）、BMI（=24 vs 24）、HbA1c （=10％ vs 10％）to observe C-P/G AUC、Homa?、HomaIR dynamic change，in order to further explore islet ?-cell function recovery degree in condition of different age、BMI、 HbA1c. Results CSII intensive therapy showed rapid and stable glucose- lowering effect. The excellent control of FPG and 2hPG in thirty patients were achieved in 3.9± 1.4days by CSII. Islet ?-cell secretary function was improved significantly，and was apparent on the first day after glycemia well-controlled(P0.05).The total four C-P/PG AUC、Homa? before and after CSII therapy , had gradually increased with the treatment time extended， and there was a clear statistical significance. HomaIR declined markly than the data before treatment, the largest range was found on the first day after glycemia well-controlled，TC、 TG also declined significantly. In sub-groups analysis, islet ?-cell function recovered better in the group of Age60、BMI24 and HbA1c=10%.Only three patients had mild hypoglycemia, who showed hunger feeling. No serious adverse events happened, for example anaphylaxis、edema and so on. Conclusion For the newly diagnosed type 2 diabetes, the excellent glycemic control can be achieved rapidly and stably, and ?-cell function can be gradually improved and insulin resistance can be reduced by the short-term CSII intensive therapy. Besides, the treatment effect was more notable in the newly diagnosed T2DM who was age60 or BMI24 or HbA1c=10%. 【key words 】 diabetes；insulin；CSII；?-cell function. 英文缩略语表 英文缩写 英文全称 中文全称 T2DM BMI OGTT HbA1c FPG 2hPG CSII IR AUC TG TC FFA LEP TNF-a MSII type 2 diabetes mellitus body mass index Oral Glucose Tolerance Test hemoglobin A1c