诊断高雄是PCOS的诊治核心传达2012 ESHRE ASRM学术会议课件.ppt

二甲双胍治疗PCOS降低雄激素 J Clin Endocrinol Metab. 2000 Jan;85(1):139-46. 二甲双胍改善青少年PCOS肾上腺功能亢进 RN=reference normal females Arslanian et al, J Clin Endocrinol Metab 2002; 87:1555–1559. 高雄在PCOS诊治具临床重要性 诊断高雄是PCOS的诊治核心 　 结语 * * background: Polycystic ovary syndrome (PCOS) is a heterogeneous disorder characterized by oligo- or anovulation (ANOV), biochemical or clinical manifestations of hyperandrogenemia (HA) and PCOs. Four phenotypes of PCOS exist [phenotype 1 (ANOV + HA + PCO), phenotype 2 (ANOV + HA), phenotype 3 (HA + PCO) and phenotype 4 (ANOV + PCO)] but the differences between them are not well studied. We compared markers of insulin resistance (IR) and endocrine characteristics between the different PCOS phenotypes * The sisters were grouped by phenotypes: PCOS [hyperandrogenemia (HA) with chronic oligoor amenorrhea, n 39], HA with regular menses (n 36), unaffected (UA; n122) * Dyslipidemia is a feature of polycystic ovary syndrome (PCOS), but its pathogenesis remains controversial.We performed this study of mothers of women with PCOS to test the hypothesis that dyslipidemia is a heritable trait in families of women with PCOS and to investigate the impact of age on reproductive and metabolic phenotypes. Fasting blood was obtained in 215 non-Hispanic white mothers of women with PCOS and 62 control women. The prevalence of metabolic syndrome was compared with that in non- Hispanic white women of comparable age from the National Health and Nutrition Examination Survey III. Mothers had higher total (P 0.001) and low-density lipoprotein (LDL) cholesterol levels (P 0.007), whereas high-density lipoprotein and triglyceride levels did not differ compared with control women. The only predictors of LDL levels in mothers were their daughters’ LDL levels (r2 0.11, P 0.001) and their own unbound testosterone levels (r2 0.04, P 0.03). The prevalence of metabolic syndrome was increased in obese (body mass index 30 kgm2) mothers compared with obese non-Hispanic white women fr