长链非编码RNAsLncRNAs在人类乳腺癌中的研究现状.PDF

网络出版时间：2018-06-01 13:57:38 网络出版地址：/kcms/detail/31.2035.Q1357.008.html 中国细胞生物学学报 Chinese Journal of Cell Biology 2018, 40(6): DOI: 10.11844/cj cb.2018.06.0029 长链非编码RNAs(LncRNAs)在人类 乳腺癌中的研究现状 毕明瑜 戴文珠 胡 斐 刘 宁 郑 玲 何吉祥 唐文如 盛苗苗* ( 昆明理工大学医学院, 衰老与肿瘤分子遗传学实验室, 昆明650500) 摘要 长链非编码RNA(long non-coding RNAs, LncRNAs)的发现改变了我们对转录和转录 后调控的认识。随着高通量测序等新技术的发展, LncRNAs 已成为癌症研究的焦点, LncRNAs的 生物学功能逐渐得到了解, 多项研究表明, LncRNAs可直接或间接地调节基因表达以及细胞生物学 功能。LncRNAs的组织特异性表达特征可用于区分正常组织与乳腺癌组织以及肿瘤发展的不同阶 段, 提示LncRNAs有望为乳腺癌的早期诊断、疗效预测以及治疗提供新的分子靶标。因此, 该文就 LncRNAs的功能以及在乳腺癌中的研究现状进行综述。 关键词 长链非编码RNA; 乳腺癌; 生物学功能 Research Status of Long Non-Coding RNAs (LncRNAs) in Human Breast Cancer Bi Mingyu, Dai Wenzhu, Hu Fei, Liu Ning, Zheng Ling, He Jixinag, Tang Wenru, Sheng Miaomiao* (Laboratory of Molecular Genetics of Aging Tumor, Medical School, Kunming University of Science and Technology, Kunming 650500, China) Abstract The discovery of long non-coding RNAs (LncRNAs) have changed our understanding of transcription and post-transcriptional regulation. With the development of new technologies such as high-throughput sequencing, LncRNAs have become the focus of cancer research. The biological functions of LncRNAs have been gradually understood. Several studies have shown that LncRNAs can directly or indirectly regulate gene expression and cell biological functions. The tissue-specific expression features of lncRNAs can be used to distinguish between normal and breast cancer ti