卟啉化合物的合成3.PDFVIP

第 19 卷 第 4 期 化　学　进　展 Vol. 19 No. 4 2007 年 4 月 PROGRESS IN CHEMISTRY 　Apr. , 2007 卟啉化合物的合成 王周锋　邓文礼 (华南理工大学材料科学与工程学院 　广州 510640) 摘 　要 　卟啉化合物在自然界中广泛存在 ,它作为辅基普遍存在于血色素、肌球素、细胞色素、接触酶 素、过氧物酶、叶绿素和细胞叶绿素中。本文主要介绍吡咯与醛酮缩合环化合成卟啉化合物的两种方法 :吡 ( ) ( β ) 咯与醛酮直接缩合环化法和模块法 ,分别论述近年来四苯基卟啉型 meso取代 和八乙基卟啉型 取代 合 成方面的研究进展。对模块法中模块单体的合成制备给予较为详细的介绍。 关键词 　卟啉 　吡咯 　合成 　二吡咯甲烷 ( ) 中图分类号: O6213 ; O62613 　文献标识码 : A 　文章编号 : 1005281X 2007 Research on Synthesis of Porphyrins Wang Zhoufeng 　Deng Wenli (College of Materials Science and Engineering , South China University of Technology , Guangzhou 510640 , China) Abstract 　Porphyrins are widely distributed in nature , and exist as the prosthetic groups in a wide variety of primary metabolites such as hemoglobins , myoglobins , cytochromes , catalases , peroxidases , chlorophylls , and bacteriochlorophylls. This article describes the current methodology for preparation of simple , symmetrical model porphyrins , as well as more complex unsymmetrically substituted porphyrins. Two methods mean direct condensation of pyrrole and aldehydes to form porphyrins and module route to form porphyrins are presented systematically. Porphyrin syntheses from monopyrroles are best described with reference to two famous porphyrins , tetraphenylporphyrin and octaethylporphyrin. The r