唑来膦酸针和伊班膦酸钠针治疗骨肿瘤临床对比研究.docVIP

唑来膦酸针和伊班膦酸钠针治疗骨肿瘤临床对比研究 　　[摘要] 目的 对比分析唑来膦酸针与伊班膦酸钠针治疗骨肿瘤的效果。 方法 方便选取2012年2月―2015年4月该院接收的62例骨肿瘤患者作为研究对象，随机分为观察组与对照组，各31例。对照组采用唑来膦酸针治疗，观察组采用伊班膦酸钠针治疗，对比观察两组患者疼痛缓解情况及不良反应发生率。结果 观察组疼痛缓解总有效率93.55%明显高于对照组的70.98%，差异有统计学意义（P0.05）；观察组不良反应总发生率为6.45%，对照组为32.26%，两组对比差异有统计学意义（P0.05）。结论 采用伊班膦酸钠针治疗骨肿瘤患者效果显著优于唑来膦酸针，且不良反应发生率低，具有一定安全性，值得推广运用。 　　[关键词] 唑来膦酸针；伊班膦酸钠针；骨肿瘤 　　[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742（2016）06（c）-0117-02 　　[Abstract] Objective To compare the efficacy of zoledronic acid and ibandronate sodium for treatment of bone tumor effect.Methods A total of 62 patients From February 2012 to April 2015 with bone tumors in our hospital were randomly divided into observation group and control group， 31 cases in each group.The control group was treated with zoledronic acid therapy， the observation group was treated with ibandronate sodium therapy.The pain relief and the incidence of adverse reactions were compared between the two groups. Results The total effective rate of pain relief in the observation group was 70.98% higher than that in the control group （93.55%）， and the difference was statistically significant （P 0.05）；The incidence rate of adverse reactions in the observation group was 6.45%， the control group was 32.26%， and the difference was statistically significant （P 0.05）. Conclusion Ibandronate sodium treatment of bone tumor patients is significantly superior to that of azole zoledronic acid and adverse reactions occurred rate is low， have a certain safety. It is worthy of popularization and application. 　　[Key words] Zoledronic acid； Ibandronate sodium ； Bone tumors 　　骨肿瘤是具有极高发病率、致残率及致死率的一种恶性肿瘤疾病，主要包括转移性骨肿瘤和原发性骨肿瘤两种类型[1]。骨肿瘤患者常伴有强烈疼痛感，对其日常生活造成了严重影响。临床医学对该疾病的治疗主要是保持骨的稳定性，避免发生骨转移瘤，缓解患者疼痛感，提升其生活质量[2]。为对比唑来膦酸针与伊班膦酸钠针治疗骨肿瘤的效果，该研究方便选取2012年2月―2015年4月该院接收的62例骨肿瘤患者进行分组研究，分别采用不同治疗，现报道如下。 　　1 资料与方法 　　1.1 一般资料 　　方便抽取2012年2月―2015年4月该院接收的62例骨肿瘤患者作为研究对象，随机分为观察组与对照组。观察组31例，男18例，女13例，年龄19～71岁，平均（45.1±4.33）岁。对照组31例，男19例，女12例，年龄18～72岁，平均（45.3±4.28）岁。两组患者性别、年龄等资料差异有统计学意义（P0.