胰岛素和血清性激素水平和子宫内膜增生相关性研究.docVIP

胰岛素和血清性激素水平和子宫内膜增生相关性研究 　　【摘要】目的：探讨胰岛素与血清性激素水平与子宫内膜增生相关性，并对其危险因素进行分析，探讨造成子宫内膜增生的危险因素，以其为临床防治提出可靠的依据。方法：纳入我院在2013年4月至2014年4月期间接受诊治的子宫内膜增生患者96例。根据子宫内膜增生程度分为子宫内膜处于增生期及分泌期（对照组）52例与子宫内膜增生过长者44例。比较两组患者一般资料、胰岛素水平及血清性激素水平，对各研究因素首先进行单因素分析，对具有统计学差异的因素给予多因素Logistic回归分析。结果：单因素分析，在胰岛素、胰岛素抵抗指数、垂体催乳素、孕酮、黄体生成素、雌二醇6个因素上具有统计学差异（P0.05）；多因素Logistic回归分析，雌二醇、垂体催乳素、胰岛素抵抗指数进入回归模型（P0.05）。结论：雌二醇、垂体催乳素、胰岛素抵抗指数为子宫内膜增生过长患者独立危险因素，三者联合检测可对子宫内膜增生过程患者的病变程度进行有效地评估，提示当患者出现E2、PRL、HOMA-IR异常时，应及早采取积极的治疗以及预防措施，防止子宫内膜增生病变进一步发展。 　　【关键词】胰岛素；血清性激素水平；子宫内膜增生；相关性 　　【Abstract】Objectives： To investigate the correlation between insulin and serum sex hormone levels and endometrial hyperplasia and analyze the risk factors causing endometrial hyperplasia to provide reliable basis for its prevention and treatment. Methods： 96 patients with endometrial hyperplasia treated in our hospital from April 2013 to April 2014 were selected. According to the degree of endometrial hyperplasia， they were divided into proliferative and secretory phase group （the control group） with 52 cases and endometrial hyperplasia mecism phase group with 44 cases. General information， insulin levels and serum sex hormone levels of the two groups were compared. Univariate analysis of each factor was first studied. Multivariate logistic regression analysis was done among factors with statistically significant differences. Results： In univariate analysis， INS， HOMA-IR， PRL， P， LH and E2 had statistically significant differences （P0.05）； in multivariate logistic regression analysis， E2， PRL and HOMA-IR were in the regression model （P0.05）. Conclusion： E2， PRL and HOMA-IR are independent risk factors for endometrial hyperplasia patients. Combined detection can be an effective assessment on the severity of endometrial hyperplasia. When E2， PRL and HOMA -IR are abnormal， early aggressive treatment and preventive measures should be taken to prevent the further development of endometrial hyperplasia. 　　【Key words】Insulin； Serum sex hormone levels；