高频超声检测血管内皮依赖性舒张功能的探讨-中国科技论文在线.PDF

高频超声检测血管内皮依赖性舒张功能的探讨 周启昌 赵水平 李江 高梅 范平 李向平 章鸣 【摘要】 目的 探讨高频超声检测血管内皮依赖舒张功能的临床价值。 方法 应用7.0 MHz探头检测原发性高血压(n=21)、 冠心病(n=21)、 和健康人(n=21) 休息时、 反应性充血、 舌下含服GTN后的肱动脉内径变化。 结果 高血压组 和冠心病组肱动脉血流介导性扩张百分比明显低于正常组〔(4.6±2.8)%、 (2.6±0.9)% vs (14.4±2.9)%， P0.05〕舌下含服GTN后肱动脉内径变化在 三组间无显著性差异〔(19.6±6.0)%、 (21.1±7.0)% vs (23.5±10.2)%， P0.05〕。 结论 原发性高血压、 冠心病存在血管内皮依赖性舒张功能失调， 高频超声能准确可靠地检测血管内皮依赖性舒张功能。 【关键词】 超声检查 内皮， 血管 血管舒张 Detection of endothelium-dependent vasodilation function with high-frequence ultrasound ZHOU Qichang, ZHAO Shuiping, LI Jiang, et al. Department of Ultrasonography, the Second Affiliated Hospital. Hunan Medical University, Changsha, 410011 【Abstract】 Objective This study is to investigate the clinical significance of detecting endothelium-dependent vasodilation function with high-frequence ultrasound. Methods The diameter of brachial arteries at rest, during reactive hyperaemia and after sublingual GTN in 63 subjects, consisted of 21 patients with essential hypertension, 21 patients with coronary heart disease and 21 controls. Results The results showed that flow-mediated dilatation in the groups with essential hypertension and coronary heart disease was much reduced in comparison with the control group 〔(4.6±2.8)%、 (2.6±0.9)% vs (14.4±2.9)%， P0.05〕. However, there was no significant difference in response to GTN among the three groups〔(19.6±6.0)%、 (21.1±7.0)% vs (23.5±10.2)%， P0.05〕. Conclusions The study indicates that endothelium-dependent vasolidation is impaired in patients with essential hypertension and coronary heart disease, high frequence ultrasound can be used to detect endothelial dysfunction. 【Key words】 Ultrasonography Endothelium, vascular Vasodilation 血管内皮是介于循环血液与血管平滑肌之间的生理屏障， 它通过释放一氧 化氮(NO)及其它血管活性物质， 在维持血管收缩舒张等方面起着关键性作用。