输血次数和不规则抗体阳性率关系探讨.docVIP

输血次数和不规则抗体阳性率关系探讨 　　【摘要】 目的 探讨输血次数与不规则抗体阳性率关系。方法 进行不规则抗体检测的输血患者5846例， 按输血次数分为≥3次者3287例， 3次以下者2559例， 采用卡式凝胶法检测患者血型不规则抗体， 同时对患者进行输血史调查。结果 5846例患者中， 不规则抗体阳性患者41例， 其中同种特异性抗体34例， 自身抗体7例， 总阳性率约0.70%。多次输血患者（≥3次）阳性率0.94%与3次以下患者阳性率0.39%相比差异具有统计学意义 　　【关键词】 输血次数；不规则抗体；免疫性溶血 　　Relationship between blood transfusion times and positive rate of irregular antibody LI Jing-lan， DU Kai-xian. Department of Blood Transfusion， Shangqiu Central Hospital， Shangqiu 47600， China. 　　【Abstract】 Objective To investigate the relationship between blood transfusion times and positive rate of irregular antibody. Methods A total of 5846 blood transfusion patients received irregular antibody test were divided into two groups according to the transfusion times. There were 3287 cases with≥3 times of blood transfusion， and 2559 cases with less than 3 times. Irregular antibody was detected by cassette gel method， and the patients’ history of blood transfusion was analyzed. Results In the 5846 cases， there were 41 cases with positive irregular antibody. Among them， there were 34 cases with the same specific antibody and 7 patients with autoantibody， and the total positive rate was 0.70%. The positive rates of repeatedly transfusion patients （≥3times） was 0.94%， and that of patients with transfusion below 3 times was 0.39%. The difference between the two groups had statistical significance （χ2=6.30， P0.05）. Conclusion Blood transfusion times are associated with the generation of irregular antibodies. The positive rate of irregular antibody increases with the increasing times of blood transfusion. 　　【Key words】 Blood transfusion times； Irregular antibody； Immune hemolysis 　　不规则抗体能够引起免疫性溶血性输血反应[1， 2]， 严重者可危及患者生命， 输血前检测不规则抗体可预防免疫性溶血性输血反应， 为临床对患者进行安全输血治疗提供重要的依据。本文通过统计分析5846例患者血型不规则抗体检测结果， 旨在探讨输血前患者血型不规则抗体检测的临床意义和输血次数与不规则抗体阳性率关系。现报告如下。 　　1 资料与方法 　　1. 1 一般资料 搜集2007年5月～2013年5月本科室5846例输血患者卡式凝胶法检测不规则抗体实验室检查资料。根据有无输血史及输血次数将患者分为两组：3次输血组（包括无输血病史患者）和≥3次输血组。3次输血组2559例， 男1749例， 女810例， 年龄16～73岁， 中位年龄58岁；≥3次输血组32