绝经前后女性血脂水平和冠脉斑块性质及血管狭窄程度相关性分析.docVIP

绝经前后女性血脂水平和冠脉斑块性质及血管狭窄程度相关性分析 　　[摘要] 目的 分析绝经前后女性血脂水平与冠脉斑块性质及血管狭窄程度的相关性。 方法 选取2011年3月～2013年3月来北京市普仁医院均经冠状动脉造影确诊的绝经前后妇女100例，比较两组患者的总胆固醇、三酰甘油、低密度脂蛋白、高密度脂蛋白浓度，非钙化斑块、混合型斑块、钙化型斑块在各自病变节段中所占的比例，血管狭窄程度。同时分析可能影响患者血管狭窄程度的因素。 结果 绝经后妇女的低密度脂蛋白浓度为（2.54±0.48）mmol/L，显著高于绝经前妇女的（2.06±0.53）mmol/L，绝经后妇女的高密度脂蛋白浓度为（1.21±0.34）mmol/L，显著低于绝经前妇女的（1.39±0.45）mmol/L，其中钙化型斑块在绝经后妇女中所占的比例为44.85%，要显著高于绝经前妇女的23.81%，差异均有统计学意义（均P 0.05）。多因素分析显示血管狭窄程度与低密度脂蛋白浓度、钙化型斑块所占比例呈正相关，而与高密度脂蛋白浓度呈负相关。 结论 绝经前后女性的低密度脂蛋白、高密度脂蛋白浓度及钙化型斑块所占比例与血管的狭窄程度密切相关。 　　[关键词] 绝经；血脂水平；冠脉斑块；血管狭窄 　　[中图分类号] R173 [文献标识码] B [文章编号] 1673-7210（2014）08（c）-0157-04 　　Correlation analysis of blood lipid level with coronary plaque nature and artery stenosis degree of women before and after menopause 　　HOU Qing1 AN Ping2 　　1.Department of Radiology， Puren Hospital of Beijing City， Beijing 100062， China； 2.Department of Cardiology， Puren Hospital of Beijing City， Beijing 100062， China 　　[Abstract] Objective To analyze the correlation of blood lipid level with coronary plaque nature and artery stenosis degree of women before and after menopause. Methods 100 cases of women before and after menopause confirmed by coronary artery scanning admitted to Puren Hospital of Beijing City from March 2011 to March 2013 were selected as the study objects. The total cholesterol， triglyceride， low density lipoprotein， high density lipoprotein， rate of non-calcified plaque， mixed plaque， calcified plaque in each lesion segment， artery stenosis degree were compared. And possible factors which influenced on artery stenosis were analyzed. Results Concentrate of low density lipoprotein of women after menopause was （2.54±0.48） mmol/L， which was significantly higher than that of women before menopause [（2.06±0.53） mmol/L]， and high density lipoprotein of women after menopause [（1.21±0.34） mmol/L] was significantly lower than that of women before menopause [（1.39±0.45） mmol/L]， ratio of calcified plaque in women after menopause was 44.85%， which was significantly h