PI3K―mTOR信号通路抑制剂抗肿瘤的研究新进展.docVIP

PI3K―mTOR信号通路抑制剂抗肿瘤的研究新进展 　　[摘要] PI3K是一种脂质激酶，控制着细胞生长、增殖、迁移、存活和血管生成，以及通过激活磷脂酰肌醇3-激酶（PI3K）、AKT和雷帕霉素靶蛋白（mTOR）促进肿瘤发展。哺乳动物mTOR的作用靶点是一种丝氨酸/苏氨酸蛋白激酶，它在细胞中广泛地表达，是一种治疗癌症的靶向目标。本文将主要论述癌症细胞系PI3K-mTOR信号通路的改变，包括乳腺癌、前列腺癌、肺癌、胰腺癌、肝癌等的作用机制。PI3K-mTOR是肿瘤治疗的有前途的靶向目标。多靶点抑制是肿瘤治疗最有效的方法，通过讨论临床试验中研究的PI3K-mTOR抑制剂药物，为将来临床抗肿瘤药物的研发提供新途径。 　　[关键词] PI3K-mTOR;PI3K-mTOR抑制剂;肿瘤治疗 　　[中图分类号] R730.5 [文献标识码] A [文章编号] 1673-7210（2015）01（a）-0161-05 　　Research new progress on inhibitors antitumor of PI3K-mTOR signaling pathway 　　WU SONG1 YU Guiping1 XUE Tao2 　　1.Department of Thoracic Surgery， Jiangyin Hospital Affiliated to Medical School of Southeast University， Jiangsu Province， Jiangyin 214400， China; 2.Department of Thoracic Surgery， Zhongda Hospital Affiliated to Medical School of Southeast University， Jiangsu Province， Nanjing 210000， China 　　[Abstract] PI3K is a kind of lipid kinase， controlling the cell growth， proliferation， migration， survival， angiogenesis and by activating PI3K， and AKT and mTOR to promote the development of tumor. mTOR for mammals rapamycin targets is a serine/threonine protein kinase， which is widely expressed in the cell， is a kind of targeted target for the treatment of cancer. This paper mainly shows PI3K cancer cell line-the change of the mTOR signaling pathways， including the mechanism of action of breast cancer， prostate cancer， lung cancer， pancreatic cancer， liver cancer， etc.. PI3K-mTOR is promising targeting tumor treatment goals. Multiple targets for inhibiting tumor is the most effective method of treatment， by discussing research in clinical trials of PI3K-mTOR inhibitor drugs， for the future clinical antitumor drug research and development to provide a new way. 　　[Key words] PI3K-mTOR; PI3K-mTOR inhibitors; Cancer treatment 　　哺乳动物的雷帕霉素靶蛋白（mammalian target of rap-amycin，mTOR）是一种磷脂酰肌醇3-激酶（phosphoinositide 3-kinase，PI3K）相关激酶，可通过mTOR信号复合物（mTOR complex，mTORC）1和mTORC2参与肿瘤细胞周期、细胞凋亡、细胞自噬等多种生物学过程，进而调节肿瘤细胞的存活、生长和增殖。在一些肿瘤细胞中经常出现mTOR信号通路的异常活化