Ⅰ级宫颈上皮内瘤变近期随访的的结果分析.docVIP

Ⅰ级宫颈上皮内瘤变近期随访的的结果分析 　　[摘要] 目的研究Ⅰ级宫颈上皮内瘤变及伴HPV感染者近期自然转归。 方法 选择符合诊断标准的Ⅰ级宫颈上皮内瘤变并能接受全程（6、12、24个月）随访者439例，分HPV阳性组116例和HPV阴性组323例，观察病变自然转归、HPV感染情况，并进行统计学分析。 结果 Ⅰ级CIN患者病变和HPV感染均存在双向转归趋势，而HPV阳性者其恶变趋势比阴性者高（P ＜ 0.05），HPV感染双向趋势比较差异无统计学意义（P 0.05）；HPV阳性者自然愈合率比阴性者低（P ＜ 0.05）。 结论 Ⅰ级CIN患者HPV阳性者可根据情况采取治疗，阴性者可随访观察。 　　[关键词] 宫颈；上皮内瘤变；Ⅰ级 　　[中图分类号] R730.1[文献标识码] B[文章编号] 1673-9701（2012）10-0030-02 　　Analysis on recent follow-up results of cervical intraepithelial neoplasia of Grade I 　　CHI Yingui1 ZHU Zhenzhen2 YU Rufen1 　　1.Department of Obstetrics and Gynecology, Third Hospital Affiliated to Wenzhou Medical College in Zhejiang Province, Ruian 325200, China; 2.Department of Obstetrics and Gynecology, Ruian City Traditional Chinese Medicine Hospital in Zhejiang Province, Ruian 325200, China 　　[Abstract] Objective To study the natural stage of termination about cervical intraepithelial neoplasia of grade I and HIV infected. Methods All of 439 follow-ups (for six, twelve or twenty-four months) of cervical intraepithelial neoplasia of grade I were selected according to a certain diagnostic standard, and were divided into HPV positive group (116 cases) and HPV negative group (323 cases). The pathological process and HPV infections were observed and analyzed statistically. Results CIN of grade I and HPV exist a two-way stage of termination while HPV positive had a higher m alignant change than that of negative (P 0.05); The natural healing rate of HPV positive was lower than that of negative (P 0.05). Conclusion HPV positive with CIN of grade I can take therapeutic schemes according to their conditions and the negative can be evaluated during follow-up period. 　　[Key words] Cervix; Intraepithelial neoplasia; GradeⅠ 　　文献报道[1]，Ⅰ级宫颈上皮内瘤变（CINⅠ）有高达60%以上的自然逆转率，依从性好、有较好地随访条件，说明随访观察是一个既合理又明智的治疗。在临床实际中由于部分患者随访条件比较差或其他情况而进行治疗，治疗过程中会给部分患者带来一定负面影响。深入研究CINⅠ自然演变过程可以给临床治疗或随访提供更多的参考依据。2005年6月～2008年6月收集我院妇科门诊符合Ⅰ级宫颈上皮内瘤变（CINⅠ）患者447例进行2年随访，观察其自然演变过程，其中8例失访，入选病例439例，现报道如下。 　　1 资料与方法 　　1.1 一般资料 　　收