补肾通督祛瘀疗法治疗强直性脊柱炎及对炎性细胞因子影响的分析-针灸推拿学专业论文.docxVIP

摘 摘 要 补肾通督祛瘀疗法治疗强直性脊柱炎及对炎性细胞因子影响的研究 补肾通督祛瘀疗法治疗强直性脊柱炎及对炎性细胞因子影响的研究 PAGE PAGE 13 PAGE PAGE 10 摘 要 目的：探讨补肾通督祛瘀疗法治疗肾阳亏虚型强直性脊柱炎的临床疗效、作 用机制及安全性。 方法：对 36 例接受补肾通督祛瘀疗法治疗的肾阳亏虚型强直性脊柱炎患者 进行临床观察，疗程 4 周,采用自身前后对照试验方法。治疗结束后评价其疗效与 安全性， 并检测治疗前后 患者 血清肿瘤坏死因子 α （ TNF-α ）、白细胞介素 -10 （IL-10）的含量。 结果：1、4 周后，显效 11 例（30.5%），有效 21 例（58.3%），无效 4 例；总 有效率 88.8%。2、临床观察指标中有 4 项（AS 症状积分、VAS 评分、晨僵时间及 胸廓活动度）于治疗前后比较差异有统计学意义 （P﹤0.01）；实验室指标中血清 肿瘤坏死因子α（TNF-α）于治疗前后比较差异有统计学意义（P﹤0.05）。3、在 4 周疗程中除有轻度口干外，无其他不良反应。 结论：补肾通督祛瘀疗法治疗肾阳亏虚型强直性脊柱炎，能显著改善患者的 临床症状与体征；降低血清炎性细胞因子的水平。 关键词：强直性脊柱炎；肿瘤坏死因子α；白细胞介素-10 Study of effect on content of serum inflammatory cytokines of patients with ankylosing spondylitis treated by the method of tonifying kidney and removing blood stasis Xiang Bing（Science of Acupuncture and Tuina） Directed by Tian Yuansheng Abstract Objective: To explore the clinical effect, mechanism and safety of the method of tonifying kidney and removing blood stasis for treatment of ankylosing spondylitis. Methods: Thirty-six cases of patients with ankylosing spondylitis treated by the method of tonifying kidney and removing blood stasis were studied clinically by using the test procedure of self-controlled contrast test method. The treatment lasted for 4 weeks. The clinical results after the treatment were compared and evaluated. The contents of tumor necrosis factor α（TNF-α）and interleukin -10 were tested before and after treatment. Results: 1. After 4 weeks, the dates of significant efficiency ,efficiency and inefficiency were 11（30.5%）, 21（58.3%）and 4 respectively, and the total effective rate was 88.8%. 2. Four clinical parameters were impoved obviously after treatment (P﹤0.01), including symptom score of AS, score of VAS, morning stiff and chest expansion. The comparison of laboratry parameter(tumor necrosis factor α) was significant before and after treatment(P﹤0.05). 3. There was no other adverse effect except thirst during the 4-week treatment. Conclusion: The method of tonifying