ScientificPrograms-発生生物学会.PDF

Scientific Programs Plenary Lectures May 11 (Thu) 9:00-11:00 Room A Chairperson: Akira Nakamura (Kumamoto Univ.) PL1-1　09:00-10:00　RNP Assembly for Intracellular transport in the Drosophila oocyte ○Anne Ephrussi (Developmental Biology Unit, European Molecular Biology Laboratory) mRNA localization to specific subcellular sites within cells is a powerful and con- served phenomenon that allows precise spatial and temporal control of protein syn- thesis. A paradigm for the study of mRNA transport is oskar mRNA, whose local- ization at the posterior pole of the Drosophila oocyte is essential for proper patterning of the embryo. Assembly of transport competent oskar mRNPs begins in the nucleus and involves splicing of the first oskar intron and the four core proteins of the Exon Junction Complex (EJC). In the cytoplasm, oskar mRNPs associate with motor proteins that transport the mRNA to its destination at the posterior cor- tex of oocyte. The importance of splicing of intron 1 is due to its requirement for deposition of the EJC and assembly of a posterior targeting element, the Spliced oskar Localization Element (SOLE), from a bipartite sequence composed of exonic sequences flanking the intron. This element forms a stem-loop structure that is posi- tioned immediately next to the EJC deposition site and is critical for efficient trans- port of oskar mRNA to the posterior pole. New findings will be presented concern- ing the central role of an RNA-binding atypical Tropomyosin-1 in the recruitment of kinesin-1 motor to oskar mRNA for its transport within the oocyte. Chairperson: Toshihiko Fujimori (NIBB) PL1-2　10:00-11:00　The blueprint of mouse development: Regionalization of cell Fates and m