常规超声联合弹性成像对乳腺癌放疗前区域淋巴结转移的评估-肿瘤学专业论文.docxVIP

万方数据 万方数据 目 录 中文摘要 ··············································································1 英文摘要 ··············································································3 英文缩写 ··············································································6 研究论文 常规超声联合弹性成像对乳腺癌放疗前区域淋巴结转移的评 估 前言 ··············································································7 材料与方法 ·····································································8 结果 ·············································································10 附图 ·············································································11 附表 ·············································································12 讨论 ·············································································16 结论 ·············································································19 参考文献 ·······································································20 综述 超声弹性成像评估乳腺癌区域淋巴结转移研究进展.………… 22 致谢 ···················································································30 个人简历 ·············································································31 中 中 文 摘 要 PAGE 10万方数据 PAGE 10 万方数据 常规超声联合弹性成像对乳腺癌放疗前区域淋巴结转移的评估 摘 要 目的：探讨常规超声联合声辐射力脉冲成像(ARFI)在评估乳腺癌放疗 前区域淋巴结转移的应用价值。 方法：收集 2015 年 1 月至 2016 年 2 月收入河北医科大学第四医院放 疗科行放疗的女性乳腺癌患者，选择放疗前常规超声(US)或定位 CT 上提 示颈部或淋巴引流区存在异常的淋巴结前瞻性入组，共 27 例患者，29 枚 区域淋巴结。所有淋巴结均行先行 US 后行 ARFI 检查，记录其特征性测 量参数。淋巴结转移以超声引导下穿刺病理阳性为金标准。收集入组患者 的基本信息和疾病资料进行相关分析。对人群及淋巴结连续性变量计算平 均值（标准差），分类变量（包括衍生变量）计算百分数。比较分类变量 关系时采用 χ2 检验。单因素逻辑回归分析各个变量与淋巴结阳性的关系。 多因素逻辑回归分析声触诊组织定量（VTQ，ARFI 主变量）在其他变量 参与下与淋巴结阳性的关系，计算风险比(OR)、95%可信区间(CI)和 P 值。 双侧 P＜0.05 定义为有统计学意义。统计软件为 SPSS 22.0。 结果：1 人群特征：本研究入组病人 27 例，平均年龄为 49.7（±12.1） 岁，年龄区间为 25～70 岁，绝经前 55.6%（15 例）；2 超声淋巴结特征： 入组淋巴结 29 枚，其中 2 例患者各收集 2 枚淋巴结。淋巴结短长轴比平 均值为 0.57（±0.20），边界欠清率为 41.4%（12 枚），VTQ 平均值为 2.50（±1.48）m/s。淋巴结转移率 34.5%（10/29 枚）；3 单因素逻辑回 归分析结果：年龄分组（≥50 岁 vs. 50 岁）及淋巴结边界状态（欠清 vs. 正常) 与淋巴结阳性有统计学意义，其相应