超声联合荧光微泡对乳腺癌转移淋巴结的释放作用-影像医学与核医学专业论文.docxVIP

第三军医大学硕士学位论文 第三军医大学硕士学位论文 PAGE PAGE 1 缩略语表 英文缩写 BC C3F8 CEUS DC 英文全称 Breast cancer Perfluropropane Contrast enhanced ultrasonography Duty cycle 中文全称 乳腺癌 全氟丙烷 超声造影 占空比 DMSO Dimethyl Sulfoxide 二甲基亚砜 DPPG 1,2-Dipalmitoyl-sn-glycero-3-phosphoglycerolsodium salt 二棕榈酰磷脂酰甘油钠 DSPC 1,2-Distearoyl-sn-glycero-3-phosphocholine 二棕榈酰磷脂酰胆碱 DiO 3，3dioetadeeyloxaearboeyanineperehlorate 细胞膜绿色荧光分子探针 FM Fluorescence microscope 荧光显微镜 FS Frozen section 冰冻切片 GLY Glycerol 丙三醇 GLU Glucose 葡萄糖 HE Hematoxylin-Eosin 苏木素-伊红 LN Lymph node 淋巴结 LM Light Microscope 光学显微镜 LSCM Laser scanning confocal microscope 激光共聚焦显微镜 MI Mechanical Index 机械指数 PDO Proplylene glycol 丙二醇 PEG-4000 US Polyethylene glycol-4000 Ultrasound 聚乙二醇 超声 SLFMs Submicron lipid fluorescence microbubbles 亚微米级荧光脂质微泡 TGC TUS Time gain compensation Therapeutic ultrasound 时间增益补偿 治疗超声 TIC Time intensity curve 时间-强度曲线 Sonorelease of DiO-microbubble to the metastatic lymph nodes of VX2 breast cancer Abstract Background: Breast cancer is an epithelial malignant tumor originated from the ductal and lobular. Infiltrating ductal carcinoma is the most common type of breast cancer in women. Mass in breast area, nipple retraction or collapse, orange peel skin and lymph node enlargement are main clinical manifestations. There are three major metastatic pathways of malignant cancer, including the hematogenous metastasis, lymphatic metastasis and direct invasion. Lymphatic system is the major passage of tumor metastasis and the systemic metastasis to important organs may involve lung, brain and bone. They will directly endanger peoples life. There are several methods for breast cancer treatment, including surgery, radiation therapy, chemotherapy and targeted drug therapy, etc. Targeted drug treatments for lymphatic metastasis include anti-lymphogenesis and regional lymphoid tissue targeted chemotherapy. In the research of therapeutic ultrasound technology, microbubble ultrasound contrast agent is widely used as a drug or gene carrier. Mic