pkpd在合理使用抗生素中意义课件.ppt

* 对于时间依赖性抗生素，随着MIC的升高，TMIC将明显缩短。 * 从这张图可以看到，尽管亚胺培南的Cmax比美平要高一些，但在Time above MIC上并无优势，对铜绿假单胞菌的Time above MIC还不如美平。 * 美平0.5g q8h, iv 60min和美平1g, q12h, iv 60min对较耐药细菌，其%TMIC是不够的。 * 4种给药方案对于MIC=4mg/L时的%TMIC，基本都可以达到40%TMIC。 * Again, I’ll talk about Monte Carlo simulation, what kinds of data need for it. One is PK distribution data calculated from Meropenem blood concentration trend and another one is Meropenem MIC distribution data against bacterial species. Monte Carlo simulation uses that data in combination and so generates %TMIC distribution. Then, as the result, Monte Carlo simulation show us