更昔洛韦治疗小儿手足口病90例临床对照的研究.docVIP

更昔洛韦治疗小儿手足口病90例临床对照的研究 　　【摘要】 目的 观察更昔洛韦治疗小儿手足口病的临床疗效。方法 将180例手足口病患儿随机分为治疗组和对照组，各90例。两组均给予口服维生素C、补液、对症等常规治疗，同时治疗组给予更昔洛韦5 mg/（kg#8226;d）加入液体中静脉滴注，对照组给予利巴韦林10～15 mg/（kg#8226;d）加入液体中静脉滴注，观察两组的临床症状、体征及不良反应。结果 治疗组临床症状及体征均较对照组消失早（P0.05）；治疗组总有效率为96.7%，对照组总有效率为82.2%（P0.05）；两组均未见明显不良反应。结论 更昔洛韦治疗小儿手足口病具有疗效显著、疗程缩短的特点，且无不良反应。 　　【关键词】 更昔洛韦； 利巴韦林； 手足口病； 小儿 　　Clinical control study on clinical effect of ganciclovir on 90 children with hand-foot-mouth disease CHEN Yi-hui,YANG Wei-bo, LI Yun-bo.The First Affiliated Hospital of Kunming Medical University,Kunming 650032，China 　　【Abstract】 Objective To observe the curative effects of ganciclovir on children with hand-feet-mouth disease（HFMD）.Methods One hundred eighty children with HFMD were randomly divided into two groups treated with conventional therapy such as vitamin C, fluid and symptomatic treatment.The treatment group were treated with ganciclovir 5 mg/（kg#8226;d） intravenously，and the control group were treated with ribavirin 10-15 mg/（kg#8226;d） intravenously.In the process of treatment，the change of symptoms, signs and adverse reactions were observed everyday.Results The clinical symptoms and signs of the patients in the treatment group disappeared earlier than that in the control group（P0.05）. The total effective rate was 96.7% in the treatment group and 82.2% in the control group（P0.05）.No obvious untoward effects were noted in both groups.Conclusion Ganciclovir was more effective than ribavirin in the treatment of children with HFMD, which could shorten the treatment period and without side effect. 　　【Key words】 Ganciclovir； Ribavirin； Hand-feet-mouth disease； Children 　　手足口病是由肠道病毒感染引起的一种非法定传染病，其最常见的肠道病毒为柯萨奇病毒A16型和肠道病毒71型（EV71），多发生于5岁以下的婴幼儿，尤多见于［1］。目前本病尚无特效的治疗方法，因此为寻求快速、有效的治疗方法，降低并发症的发生，对2008年6月～2010年12月在笔者所在医院确诊的180例手足口病患儿，采用更昔洛韦治疗，并与采用利巴韦林组作疗效对比，取得满意效果，现报道如下。 　　1 资料与方法 　　1.1 一般资料 选择2008年6月～2010年12月笔者所在医院收治的手足口病患儿180例为观察对象，均符合以下5条诊断：（1）流行病学资料，有手足口病接触史；（2）发热，多表现为中等发热，偶有高热（体温在39 ℃以上）；（3）疱疹，以手足掌部为特征，疱疹基底部绕有炎性红晕，疱内液