儿童与青少年癫痫痫性发作与海马代谢物异常相关性磁共振波谱探讨-影像医学与核医学专业论文.docxVIP

侧海马区域均会出现神经元细胞功能紊乱，胶质细胞增生，其中颞叶癫痫以致痫 侧改变最为明显；颞叶癫痫病人双侧海马的 NAA/(Cho+Cr)比值与癫痫病人痫性 发作起始时间、痫性发作频率及癫痫病人病程无明显相关性；以上提示儿童及青 少年颞叶癫痫可能在癫痫早期就对海马区就形成了病理损害，本实验未能证明这 种损害具有累积效应，而这种损害究竟是进行性或是跳跃式发展的过程，仍需要 进一步结合成人癫痫来讨论。 关键词 颞叶癫痫 癫痫发作频率 痫性病程 相关性 磁共振波谱 Correlation of seizure with metabolic dysfunction in hippocampus by 1H-magnetic resonance imaging in epilepsy Department of Radiology of Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Candidate Zhang Jingtao Supervisor Prof.Xu Haibo Abstract Objective To explore the correlation between seizure and metabolic dysfunction of neuron and glia cell in the hippocampus by MRS in children and adolescents with temporal lobe epilepsy (TLE) ，and to improve our understanding of progressive changes and the underlying mechanisms in the focal temporal lobe epilepsy. And a preliminary study of secondary epilepsy with hippocampal sclerosis may exist between the relationships. Methods and Materials 38 teenagers and children patients were diagnosed as TLE by comprehensive use of clinical history and neurological examination, scalp EEG with sphenoidal electrodes, conventional magnetic resonance imaging (cMRI); There were 23 men and 15 women with the age of 7 to 22 years (mean age, 12.7 years). 10 healthy volunteers with known history of no neurological disease were recruited as control. Choose independent sample t-test method, we think P ≤0.05 significant statistical significance.Furthermore,analysis was performed in the correlation of seizure and duration with the ratio of NAA/ (Cho+Cr) in the hippocampus ipsilateral to epileptogenesis foci and contra lateral to epileptogensis foci; Another 10 cases of secondary with epilepsy, to analyze the metabolites between secondary bilateral hippocampal between with normal controls have obvious difference. Results The ratio of NAA/ (Cho+Cr) was significantly decreased in the head, body and tail of the hippocampus in the TLE compared to the control group. But in the TLE pa