现代营养学之自由基疾病教学文稿.pptVIP

5.5 Free Radical and Gerontal Disease (老年病) Alzheimer’s disease 老年痴呆 Parkinson’s disease 帕金森症 Cataract 白内障 Skin aging 皮肤老化 6 Defense Against ROS Electron transport chain 0.2%O2→O2·－ ROS 6.1 Defense system in mitochondrion 1) Cytochrome c Cyt c-Fe3+ + O2·－ → Cyt c-Fe2+ + O2 Cyt c-Fe2+ + H2O2 → Cyt c-Fe3+ +H2O Eliminate HO· 2) Co Q Q + H+ QH2 6.2 Antioxidant enzyme 1) Superoxide Dismutase O2·－ H2O2 SOD Without SOD, reaction rate=5×105 (L·mol-1·s-1) With SOD, reaction rate=1.6×109 (L·mol-1·s-1) 104倍 2) Catalase H2O2 H2O Catalase O2 + Exist in peroxisomes of all the cells