短疗程适形非常规放疗同步EP的方案化疗Ⅲ期非小细胞肺癌68例.docVIP

短疗程适形非常规放疗同步EP的方案化疗Ⅲ期非小细胞肺癌68例 　　【摘要】 目的 探讨非小细胞肺癌(NSCLC)短疗程适形非常规放疗同步EP方案化疗的疗效。方法 Ⅲ期NSCLC患者68例，第1周采用适形常规放疗，2GY/次,照射5次，周六、日休息；然后采用常规大剂量放疗3GY/次，5次/周，照射10次；第4周与第1周治疗方式相同；第5周3GY/次，照射3次；共31 d完成全部放疗，等效生物剂量为70GY。化疗采用EP方案：第1、2、3天VP-16 80 mg/m2，静脉滴注；第1天PDD 60 mg/m2 静脉滴注。21 d为1个周期，于照射当天同时行静脉化疗。同步放化疗结束后第3周再行3周期强化静脉化疗。结果 近期有效率为89．7%，1、2、3年生存率为73．5%、39．7%、22．1%；中位生存期为19．6个月。结论 短疗程适形非常规放疗同步EP方案化疗Ⅲ期NSCLC有较好疗效，不良反应可以耐受。 　　【关键词】 肺癌；适形放疗；短疗程；非常规；化疗；同步 　　 　　Synchro EP of extraordinary gauge of short course of treatment shape suitable radiotherapy scheme chemotherapy Ⅲ in non-cellule lung cancer phase of 68 cases 　　 　　【Abstract】 Objective Explore the treatment effect of non-cellule lung cancer(NSCLC)owes a course of treatment the synchro EP of extraordinary shape gauge suitable radiotherapy scheme chemotherapy.MethodsⅢex-pects the NSCLC patients of 68 cases,the first cycles adopted the shape routine radiotherapy suitable,2 GY/irradiate 5 times,gradually have a rest Saturday, Adopt large dosages of routine then radiotherapy 3 GY/are inferior,5 times of//cycles,irradiate 10 times;The fourth cycles and the first cycles were treated is identical;the Fifth cycle 3 GY/irradiate 3 times,31 days accomplishes all radiotherapies,equivalent living things dosages are 70 GY.The chemotherapy adopt the EP scheme:VP-16 80 mg/m2 quiescent point the 1 st,2nd,3nd day; PDD 60 mg/m2 quiescent point 1 st day.21 days is a period,in irradiating the very day performing the vein chemotherapy at the same time.Put in a chemotherapy synchroly 3 periods ending last third strengthen the vein chemotherapy.Results The efficiency in the near future is 89．7%,the survival rate is 73．5%,39．7%,22．1%for1,2,3 years respectivelly; The median place life cycle is 19．6 months.Conclusion Synchro EP of extraordinary gauge of short course of treatment shape suitable radiotherapy scheme chemotherapy Ⅲ scheduled time NSCLC has the fairly treatment effect,The patient could endure the side-effects. 　　【Key words】 Lung cancer;Shap