头颈部原发性非霍奇金恶性淋巴瘤50例临床分析..docVIP

头颈部原发性非霍奇金恶性淋巴瘤50例临床分析 关键词】头颈部肿瘤 】目的探讨头颈部原发性非霍奇金淋巴瘤的 临床特征及免疫学表型特点。方法对经病理确诊的50例头 颈部原发性非霍奇金淋巴瘤的临床资料和细胞免疫表型做 回顾性总结分析。结果本组病例发病高峰年龄为20~40岁， 原发部位鼻腔最多，其次为鼻咽部、扁桃体及舌底。临床表 现主要以原发器官的症状为主，缺乏特异性。体征多以结节 状或菜花状肿块型最多，其次为肿块伴溃烂型，单纯的溃烂 型较少。结论细胞免疫学表型结果显示：来源于T细胞者 占70 %，来源于B细胞者占30%o鼻腔原发性NHL以T/NK细 胞为主，占56%o鼻咽部、扁桃体原发性丽L以B细胞为主， 占 22% o 关键词】头领部肿瘤；淋巴瘤，非霍奇金；免疫组 织化学 Abstract 】 Object ive Wesoughttoinve stigatetheclinical featuresaswellasch aracteristicsofthe immunologicalforms withrespecttotheid iopathicallyhead-n ecknon-Hodgkin’ sly mphoma. Methods Our studywasbasedonthe analysisandconclus ionsof50instancesw denceofthisdisease hamongsttheagebetw iopathymostcommon1 vityfollowedbythen ndlastlyunderneathcalcharacteristicsotheoriginallyinfe relackingofsymptom denceofthisdisease hamongsttheagebetw iopathymostcommon1 vityfollowedbythen ndlastlyunderneath calcharacteristics otheoriginallyinfe relackingofsymptom softuberculousorca enulceroustumors celluarimmunology hatthoseoriginatin tfor70%；whilstthos cellsaccountfor30% ssociatedwithnasal ibutedtoT/NK-cells hereasthoseassocia fferfromtheidiopat hicNHLinthehead-ne ckarea ， examiningre trospectivelythecl inicalrecordsandch aracteristicsoftheimmunologicalforms aracteristicsofthe immunologicalforms associatedwiththeWefoundthattheinci associatedwiththe Wefoundthattheinci wasparticularlyhig een20?40 ， withtheid yfoundinthenosalca asopharynx ， tosil ， a thelingua. Theclini weremostlylimitedt ctedorgans ， therefo smainlytooktheform uliflowertumors ， th w ithveryfew Basedon ourresultssuggestt gfromT-cellsaccoun eoriginatingfromB- .TheidiopathicNHLa cavityismainlyattr accountingfor56%；w tedwiththenasophar ynxandtosilmightbe mostlyattributedto B~cel 1 saccountingf or22%. Keywords ] head-necktumors；ly mphoma, non-Hodgkin ； immunohistochemis try 恶性淋巴瘤是来自淋巴系统及网状内皮系统的非上皮 性恶性肿瘤。非霍奇金淋巴瘤常发生在淋巴结内，而首发于 琳巴结外的恶性淋巴瘤仅占全身恶性淋巴瘤的io°ri5%，易 于广泛播散。头颈部恶性淋巴瘤多见于颈淋巴结、鼻腔、鼻 咽部、扁桃体、咽后壁、上领窦、舌等。其恶性程度高，临 床表现复杂，预后较差，近年来生存率有所提高，常规的病 理检查有时难以明确诊断，应在常规病理切片检查的基础上 再做免疫组化检查。鼻腔和咽喉部淋巴瘤在西欧占全部淋