维格列汀联合二甲双胍治疗肥胖型2型糖尿病160例疗效的探讨.docVIP

维格列汀联合二甲双胍治疗肥胖型2型糖尿病160例疗效的探讨 　　[摘要]目的 探讨维格列汀联合二甲双胍治疗肥胖型2型糖尿病的疗效。方法 选取吉林省人民医院内分泌科于2013年1月―2014年12月收治的肥胖型2型糖尿病患者160例，随机分为两组；其中二甲双胍组给予二甲双胍，联合治疗组同时给予维格列汀和二甲双胍；6个月后，比较两组患者BMI、FPG、2hPBG、HbA1c、GLP-1、TC、TG、HDL-C、LDL-C等指标。结果 治疗后两组患者的BMI、FPG、2hPBG、HbA1c、TC、TG、LDL-C等指标与治疗前比较明显降低，而GLP-1与HDL-C水平明显升高，差异有统计学意义（P0.05）；治疗后联合治疗组患者的BMI、FPG、2hPBG、HbA1c、TC、TG、LDL-C等指标与二甲双胍组比较下降更为明显，而GLP-1与HDL-C水平升高更为明显，差异有统计学意义（P0.05）。结论 维格列汀联合二甲双胍治疗肥胖型2型糖尿病疗效明显，值得推广。 　　[关键词]维格列汀；二甲双胍；疗效 　　[中图分类号]R5 [文献标识码]A [文章编号]1674-0742（2015）04（b）-0108-02 　　Clinical Observation of Vildagliptin Combined with Metformin in Treatment of Type 2 Diabetes with Obesity 　　XIE Likai QI Chenrui SUN Yadong 　　Endocrinology Department，The peoples hospital of Jilin province， Changchun， Jilin Province，130000 China 　　[Abstract] Objective To explore the efficacy of vildagliptin combined with metformin in treatment of type 2 diabetes with obesity. Methods Patients （160 cases） who came to endocrinology department of Jilin province peoples hospital from January 2013 to December 2014 were randomly divided into two groups； the metformin group was given metformin alone and the combination group was given vildagliptin and metformin； after 6 month， the indexes of two groups such as BMI， FPG， 2hPBG， HbA1c， GLP-1， TC， TG， HDL-C， LDL-C were observed. Results After treatment，compared with that before treatment， BMI， FPG， 2hPBG， HbA1c， TC， TG and LDL-C significantly decreased， and GLP-1， HDL-C significantly increased，the differences were statictically significant（P0.05）； after treatment，BMI， FPG， 2hPBG， HbA1c， TC， TG and LDL-C in combination group dropped off more sharply， and GLP-1， HDL-C were rise more apparent than those in metformin group，the differences were statictically significant（P0.05）. Conclusion Vildagliptin combined with metformin in treatment of type 2 diabetes with obesity has a better effect， which is worthy of clinical popularization and application. 　　[Key words] Vildagliptin； Metformin； Efficacy 　　随着社会经济的发展及人们生活方式的转变