法舒地尔治疗冠心病心力衰竭临床的的疗效观察.docVIP

法舒地尔治疗冠心病心力衰竭临床的的疗效观察 　　[摘要] 目的 观察盐酸法舒地尔对冠心病心力衰竭的临床疗效。 方法 将93例冠心病心力衰竭患者随机分成两组，对照组46例给予常规治疗，治疗组47例在常规治疗的基础上加用盐酸法舒地尔。两组在治疗前及治疗后3个月末进行彩色多普勒超声心动图检查，获得左心室收缩末容量指数和舒张末容量指数及左心室射血分数、左心室体质量指数，治疗过程中观察并记录患者症状、体征、心率、血压及不良反应，治疗前后常规测定血脂、肾功能、肝功能、尿酸、电解质、血糖等各项生化指标的变化。 结果 盐酸法舒地尔治疗冠心病心力衰竭临床效果明显，临床症状显著改善，总有效率为89.3%，治疗后左心室收缩末容量和舒张末容量明显降低，左心室射血分数明显提高，与治疗前和对照组比较差异有统计学意义（P 0.05），未发现明显不良反应。 结论 盐酸法舒地尔可有效抑制心室重构，缓解心力衰竭症状。 　　[关键词] 冠心病心力衰竭；法舒地尔；心室重构 　　[中图分类号] R541.4；R541.6 [文献标识码] B [文章编号] 1673—9701（2012）24—0056—02 　　The clinical effects of fasudil hydrochloride on patients with heart failure secondary to coronary heart disease 　　LIU Keqiang HUANG Liangshun HU Yuping 　　First Department of Internal Medicine， Ganxian Peoples Hospital of Jiangxi Province， Ganxian 341100， China 　　[Abstract] Objective To evaluate the clinical effects of fasudil hydrochloride on patients with heart failure （HF） secondary to coronary heart disease （CHD）. Methods Ninety—three patients with HF secondary to CHD were randomly divided into two groups： control group （46 cases） and treatment group （47 cases）. Patients in control group received conventional therapies， and patients in treatment group received fasudil hydrochloride besides conventional therapies. The detection indicators of end systolic volume index， end diastolic volume index， ejection fraction and quality index number of left ventricular of these patients were measured by color Doppler echocardiogram on the day and after three months of beginning to accept treatment. The symptoms， physical signs， heart rates， blood pressures and adverse reactions of these patients were observed and recorded in therapeutic process. The biochemical indicators of blood lipid， renal function， liver function， uric acid， electrolytic blood sugar were routinely detected before and after treatment and analyzed the changes. Results Fasudil hydrochloride had markedly clinical effect for patients with heart failure secondary to coronary heart disease. The clinical symptoms were improve