结核性脑膜炎采用脑脊液置换联合鞘内注射的应用效果.docVIP

结核性脑膜炎采用脑脊液置换联合鞘内注射的应用效果 　　[摘要] 目的 分析结核性脑膜炎采用脑脊液置换联合鞘内注射应用效果。 方法 收集我院2016年3月～2017年3月间结核性脑膜炎患者共118例，根据随机分组原则分为常规组（n=59）和实验组（n=59），常规组接受常规药物治疗，实验组接受脑脊液置换联合鞘内注射治疗，比较两组患者疗效。 结果 实验组患者治疗总有效率为96.61%（57/59）；常规组患者治疗总有效率为81.36%（48/59），实验组患者治疗总有效率显著高于常规组，差异有统计学意义（P0.05）；实验组患者症状缓解时间明显短于常规组，差异有统计学意义（P0.05）。 结论 除了常规药物治疗外，采用脑脊液置换联合鞘内注射能够缩短患者的症状缓解时间，提升整体治疗效果，临床中值得推广使用。 　　[关键词] 结核性脑膜炎；脑脊液置换；鞘内注射；异烟肼 　　[中图分类号] R529.3 [文献标识码] B [文章编号] 1673-9701（2018）02-0066-03 　　[Abstract] Objective To analyze the application effect of cerebrospinal fluid replacement combined with intrathecal injection in the treatment of tuberculous meningitis. Methods A total of 118 patients with tuberculous meningitis in our hospital were collected from March 2016 to March 2017. According to the principle of randomization， the patients were divided into routine group（n=59） and experimental group（n=59）. The routine group was given routine drug treatment， and the experimental group was given cerebrospinal fluid replacement combined with intrathecal injection therapy. The efficacy of two groups of patients were observed and compared. Results The total effective rate in the experimental group was 96.61%（57/59）； the total effective rate in the patients in the routine group was 81.36%（48/59）. The total effective rate in the experimental group was significantly higher than that in the routine group，the difference was statistical significance between the two groups（P0.05）； the symptom relief time in the experimental group was significantly shorter than that in the routine group， the difference was statistical significance between the two groups（P0.05）. Conclusion In addition to the conventional drug treatment， the combination of cerebrospinal fluid replacement and intrathecal injection can shorten the time for symptom relief in the patients and improve the overall therapeutic effect. It is worthy of promotion and application in clinical practice. 　　[Key words] Tuberculous meningitis；Cerebrospinal fluid replacement；In