米非司酮治疗围绝经期功能失调性子宫出血90例的的疗效观察.docVIP

米非司酮治疗围绝经期功能失调性子宫出血90例的的疗效观察 　　摘要：目的：探讨米非司酮治疗围绝经期功能失调性子宫出血的疗效。 方法：入选的90例围绝经期功能失调性子宫出血患者均为我院2008年1月-2010年6月的住院患者，给予米非司酮治疗，观察用药前后血清FSH、LH、E2、P的变化情况。结果：全部患者用药前、用药后3个月B超监测子宫内膜厚度分别为（1.2±0.3）cm、（0.5±0.2）cm，子宫内膜厚度治疗后3个月明显较治疗前缩小，经t检验分析，差异有统计学意义（P＜0.05)。用药前后FSH、LH、E2、P变化情况比较：服药后3个月FSH、LH较用药前比较均明显下降，E2、P较用药前比较均明显升高，经t检验分析，差异均有统计学意义（P＜0.05）。结论：米非司酮治疗围绝经期功能失调性子宫出血疗效确切，副作用少，值得临床推广。 　　关键词：围绝经期 米非司酮 子宫内膜 　　 　　 Mi Feisi the alkone treatment encircles menopause function rheomalaxis uterine hemorrhage 90 example curative effect observation 　　Zhang Aijun 　　Abstract:Objective:Searches begs for food non-Si Tong to treat encircles the menopause function rheomalaxis uterine hemorrhage the curative effect.Methods:The selected 90 examples encircle the menopause function rheomalaxis uterine hemorrhage patient for my courtyard in January,2008 - June,2010 in hospital patient,gives Mi Feisi the alkone treatment,around the observation medication blood serum FSH,LH,E2,the P change situation.Results:Before the complete patient applies drugs,applies drugs the latter 3 month B ultra monitor endometrium thickness respectively be (1.2±0.3)cm,(0.5±0.2)cm before,endometrium thickness treats the latter 3 months to treat obviously reduces,after the T-test analysis,the difference has statistics significance (P0.05).Around medication FSH,LH,E2,P change situation comparison:Before takes medicine latter 3 month FSH,LH applies drugs quite is even drops obviously before,E2,P apply drugs quite are even the obvious ascension,after the T-test analysis,the difference has statistics significance (P0.05).Conclusion:Mi Feisi the alkone treatment encircles the menopause function rheomalaxis uterine hemorrhage curative effect to be accurate,the side effect are few,is worth the clinical promotion. 　　Keywords:Encircles menopause Mi Feisi the alkone Endometrium 　　【中图分类号】R453 【文献标识码】B 【文章编号】1008-1879(2010)12-0085-01 　　 　　临床上应用药物治疗围绝经期功能失调性子宫出血的方法较多，选用一种安全可靠的药物成对于疾病的恢复至关重要。米非司酮是孕激素受体拮抗剂，研究报道，其对子宫内膜增生具有特有的抗雌激素调节机制，