糖皮质激素气雾剂治疗季节性变应性鼻炎的的疗效观察.docVIP

糖皮质激素气雾剂治疗季节性变应性鼻炎的的疗效观察 　　【摘要】 目的 探讨单用糖皮质激素气雾剂治疗季节性变应性鼻炎的临床疗效，旨在减少药物不良反应的发生。方法 选择季节性变应性鼻炎224例，随机分两组各112例，实验组应用肾上腺皮质激素鼻喷雾剂于每晨各喷两侧鼻腔一次；对照组应用氯雷他定+肾上腺皮质激素气雾剂喷鼻一次。连续应用15~20 d左右。结果 根据症状及体征记分法评定疗效，试验组患者总有效率为92．86%，对照组总有效率为93．75%，有效率两组比较无显著性差异(P0．05)。试验组患者用药后观察不良反应发生率16．07%，对照组不良反应发生率为26．79%，不良反应发生率两组比较有显著性差异(P0．01)。结论 单纯鼻腔局部应用皮质激素鼻喷雾剂，可以有效的控制季节性变应性鼻炎的临床症状，明显减少联合用药带来的不良反应。? 　　【关键词】变应性；鼻炎；季节性；药物疗法；肾上腺皮质激素 　　?? 　　Different drug curative effect observation to seasonal allergic rhinitis 　　 　　LIU Yan,LIU Xin-yi,LI Da-jian,et al.Department of Otolaryngology Head and Neck Surgery，Weihai Hospital,Medical College of Qingdao University,Shandong，264200，China 　　? 　　【Abstract】 Objective To investigate pre-attact and post-attact drug treatment curative effect of seasonal allergic rhinitis; to reduce drug adverse effect utmostly.Methods 224 cases of seasonal allergic rhinitis were divided into two groups.Each had 112 cases.The experimental group used adrenal cortex hormone nasal spraying agent one time a day by each side.The control group used Loratadine Tablets and adrenal cortex hormone nasal spraying agent one time a day about 15~20 days continuously.Results Evaluate the curate effect according to the symptom and physical sign.The effective rate of experimental group was 92．86%,the control group was 93．75%.The effective rate of two groups had no remarkable difference(P0．05).The adverse incidence rate of experimental group was 16．07%,the control group was 26．79%.The adverse incidence rate of two groups had remarkable difference(P0．01).Conclusion Only using cortex hormone nasal spraying agent can prevent the clinical symptom of seasonal allergic rhinitis,reduce adverse effect by combined using drug remarkatablly.? 　　【Key words】Allergic; Rhinitis; Seasonal; Drug Therapy;Adrenal Cortex Hormone 　　? 　　皮质类固醇鼻喷雾剂及抗组胺药物治疗变应性鼻炎(allergic seasonal rhinitis,AR)疗效肯定，但屡见报道[1-3]。由于抗组胺药物的不良反应较明显，给患者的工作及生活带来了诸多不便。为此，自2002-2006年间，单用皮质类固醇鼻喷雾剂，对有固定季节的AR患者进行治疗，同期设皮质类固醇鼻喷雾剂联合氯雷他定(loratadine tabl