教育论文米非司酮联合甲氨蝶呤治疗异位妊娠临床分析.docVIP

米非司酮联合甲氨蝶呤治疗异位妊娠临床分析 目的：比较分析米非司S同练联合甲氨蝶吟治疗异位妊娠的 临床效果。方法：以广西医科大学第一附属医院2013年10月至2014 年10月120例采取保守治疗的异位妊娠保患者为研究对象，对患者 进行随机分组，三组均每隔12小时服用米非司酮25mg/次，连续服 用3d，甲组采用甲氨蝶呤单次注射1 mg/（kg ?次），乙组采用甲氨蝶 呤分5次注射，每次0.4 mg/（kg ? d），丙组在超声引手下采用异位 妊娠囊穿刺注射甲氨蝶呤40mg杀胚木。对三组患者的临床疗效进行 回顾性分析。结果：甲组成功率95%，乙组成功87. 5%，丙组成功率 为90%,三组成功率无显著差异（P〉0. 05），甲组不良反应发生率为 15%,乙组不良反应发生率为32.5%，丙组不良反应发生率为12.5%， 乙组与甲组比较具有统计学差异（P0. 05），乙组与丙组比较具有统 计学差异（P〈0. 05），甲组与丙组比较无统计学差异（P〉0. 05）。结论: 三种米非司酮联合甲氨蝶呤治疗异位妊娠的临床效果均较理想，但采 用分次肌注的不良反应较多，超声引导下采用异位妊娠囊穿刺注射存 在一定的异位妊娠包块破裂风险，米非司酮联合甲氨蝶呤单次注射的 疗效确切，安全性较高，可进行临床推广。 关键词：米非司酮，甲氨蝶呤，异位妊娠，临床 Clinical analysis of mifepristone combined with methotrexate in treatment of ectopic pregnancy Guo Peiqin Guangxi Baise national health school 533000 Abstract: Objective: To compare the clinical effect of mifepristone and practice ana lysis combined with methotrexate in treatment of ectopic pregnancy. Methods: in the First Affiliated Hospital of Guangxi Medical University in 2013 October to 2014 October 120 cases of ectopic pregnancy conservative treatment the patient as the research object, were randomly assigned to three groups of patients, taking mifepristone 25mg/ once every 12 hours, continuous use of 3D, group A with methotrexate and a single injection of 1 mg/ (kg times), group B with methotrexate 5 times injection, each 0.4 mg/ (kg, d), group C in ultrasound guided puncture injection of methotrexate by ectopic pregnancy sac 40mg killing embryo surgery. The clinical efficacy of the three groups were ana I yzed retrospect i ve I y. Results: group a success rate of 95%, group B was successful in 87.5%, the success rate of group C was 90%, the success rate of three groups had no significant difference (Pgt; 0.05)， adverse reaction incidence was 15% in group A, group B and adverse reaction rate was 32.5% in group C, the incidence rate of adverse reaction was 12. 5%, group B and group A than has a statistically significant difference (Plt; 0.05), the comparison group B and group C has a statisticaIly