还原型谷胱甘肽联合介入治疗对原发性肝癌疗效及肝功能的影响的研究.docVIP

还原型谷胱甘肽联合介入治疗对原发性肝癌疗效及肝功能的影响的研究 　　[摘要] 目的 探讨还原型谷胱甘肽联合介入治疗对原发性肝癌疗效及肝功能的影响。 方法 选取2014年6月～2017年3月我院肿瘤科收治的71例原发性肝癌患者，随机分为观察组（还原型谷胱甘肽联合介入治疗）36例、对照组（常规药物联合介入治疗）35例，比较两组肝功能指标及疗效。 结果 治疗前，两组谷丙转氨酶（ALT）、谷草转氨酶（AST）、碱性磷酸酶（ALP）、总胆红素（TBIL）水平比较差异无统计学意义（P0.05）；治疗后，观察组各项肝功能指标均优于对照组，差异具有统计学意义（P0.05）。观察组治疗有效率为86.11%，明显高于对照组的62.86%，差异具有统计学意义（P0.05）。 结论 还原型谷胱甘肽能改善原发性肝癌患者接受介入治疗引起的肝功能损伤，提高治疗的有效性及安全性，值得临床推广采用。 　　[关键词] 还原型谷胱甘肽；介入治疗；原发性肝癌；肝功能 　　[中图分类号] R735.7 [文献标识码] A [文章编号] 1673-9701（2017）30-0004-04 　　[Abstract] Objective To investigate the effect of reduced glutathione combined with interventional therapy on primary liver cancer and liver function. Methods 71 patients with primary liver cancer who were admitted to the department of Oncology in our hospital from June 2014 to March 2017 were selected. They were randomly divided into 36 cases in the observation group（reduced glutathione combined with interventional therapy）， and 35 cases in the control group （conventional drugs combined with interventional therapy）. Liver function indices and efficacy were compared between the two groups. Results There were no statistically significant differences in the levels of ALT， AST， ALP and TBIL before the treatment between the two groups（P0.05）； after the treatment， the liver function indices in the observation group were better than those in the control group， and the differences were statistically significant（P0.05）， the effective rate in the treatment group was 86.11%， which was significantly higher than that in the control group（62.86%）， the difference was statistically significant（P0.05）. Conclusion Reduced glutathione can improve the liver injury induced by interventional therapy in the patients with primary liver cancer， and improve the efficacy and safety of treatment， which is worthy of clinical promotion and application. 　　[Key words] Reduced glutathione； Interventional therapy； Primary liver cancer； Liver function 　　原?l性肝癌属隐匿性疾病，其发病率居恶性肿瘤第5位，病死率居第3位，在我国患病人数占据全球的55%，且发病率、病死率均呈上升趋势[1]