儿童川崎病冠状动脉病变危险因素剖析.docVIP

儿童川崎病冠状动脉病变危险因素剖析 　　[摘要] 目的 探讨川崎病（KD）合并冠状动脉病变的危险因素。 方法 回顾性分析2014年1月～2016年12月本院169例KD住院患?旱牧俅沧柿希唤?169例KD分为A、B两组，其中A组为KD合并冠状动脉病变，B组为KD不伴冠状动脉病变；采用独立样本t检验分析两组年龄、发热天数、白细胞数、超敏C反应蛋白、血沉、血小板数、血清白蛋白、血钠、D二聚体与KD冠状动脉病变的关系；同时采用ROC曲线分析血清白蛋白、血钠、D二聚体预测冠状动脉病变的效能。 结果 KD冠状动脉病变发生率为36.69%。A、B组患儿血清白蛋白、血钠、D二聚体的差异有统计学意义（P0.92 mg/L是KD合并冠状动脉病变的危险因素。 结论 KD的主要危害是冠状动脉病变；血清白蛋白0.92 mg/L是KD合并冠状动脉病变的危险因素。 　　[关键词] 川崎病；冠状动脉病变；危险因素；D二聚体 　　[中图分类号] R725.4 [文献标识码] B [文章编号] 1673-9701（2018）03-0056-04 　　Analysis on the risk factors of coronary artery disease in children with Kawasaki disease 　　ZHOU Fang1 XU Jun2 JIA Lihong1 ZHOU Jielin2 ZHANG Xiaoxiao2 YANG Ming2 　　1.Department of Nephrology， Hangzhou Childrens Hospital， Hangzhou 310014， China； 2.Department of Neurology， Hangzhou Childrens Hospital， Hangzhou 310014， China 　　[Abstract] Objective To investigate the risk factors of Kawasaki disease （KD） complicated with coronary artery disease. Methods The clinical data of 169 children with KD who were hospitalized in our hospital from January 2014 to December 2016 were retrospectively analyzed； the 169 cases of KD were divided into two groups： group A and group B. Group A was KD complicated with coronary artery disease， and group B was KD without coronary artery disease； the relationship between age， fever days， white blood cell count， high sensitivity C-reactive protein， erythrocyte sedimentation rate， platelet count， serum albumin， serum sodium， D dimer and KD complicated with coronary artery disease were analyzed by independent sample t test； at the same time， ROC curve was used to analyze the efficacy of serum albumin， serum sodium and D dimer in predicting coronary artery disease. Results The incidence rate of KD coronary artery disease was 36.69%. The differences of the levels of serum albumin， serum sodium and D dimer in children in group A and B were statistically significant（P0.92 mg/L were the risk factors of KD complicated with coronary artery disease. Conclusion The main risk of KD is corona