黄龙清幽汤治疗幽门螺杆菌感染的的疗效观察.docVIP

黄龙清幽汤治疗幽门螺杆菌感染的的疗效观察 　　[摘要] 目的:探讨黄龙清幽汤对幽门螺杆菌(Hp)的根除作用。方法:选择101例Hp阳性消化性溃疡患者,随机分为两组。治疗组51例,采用自拟黄龙清幽汤,每日1剂,服用3个月。对照组50例,采用埃索美拉唑(20 mg,每日2次)加甲硝唑(400 mg,每日2次),加阿莫西林(1 000 mg,每日2次),治疗7 d后继续用埃索美拉唑20 mg,每日1次,服用3周。疗程结束4周后复查胃镜和Hp,观察Hp根除率,症状缓解率和溃疡愈合率。结果:治疗组和对照组Hp根除率分别为90.2%和74.0%,两组比较,差异有统计学意义(P0.05)。结论:黄龙清幽汤治疗幽门螺杆菌效果显著。 　　[关键词] 消化性溃疡;幽门螺杆菌;黄龙清幽汤;埃索美拉唑;甲硝唑;阿莫西林 　　[中图分类号] R254 [文献标识码]A[文章编号]1673-7210(2009)07(b)-080-02 　　 　　Curative effect observation of Helicobacter pylori infection treated by Huanglong Qingyoutang 　　LU Wei1, GONG Meijin2 　　(1.The 6th Peoples Hospital of Shenzhen City, Shenzhen 518052, China; 2.Xili Peoples Hospital of Shenzhen City, Shenzhen 518055, China) 　　[Abstract] Objective:To study the effect of Huanglongqingyoutang for Helicobacter pylori(Hp) infection. Methods:101 Patients with Hp infection suffering from peptic ulcer were divided into to treatment group and control group. The treatment group were treated by Huanglongqingyoutang. The control group were treated by esomeprazole (20 mg, twice a day) , metronidazole (400 mg, twice a day) and amoxicillin (1 000 mg, twice a day) for one week and then were treated by esomeprazole (20 mg,every day)for another three weeks. Four weeks later, the Hp eradication, symptoms, peptic ulcer healing were observed. Results:The Hp eradication rate between the treatment group and control group were 90.2%, 74.0%, respectively. There was significant difference between the two groups (P0.05 ). Conclusion: Effect of Huanglongqingyoutang for Hp infection is remarkable. 　　[Key words] Peptic ulcer; Helicobactor pylori; Huanglongqingyoutang; Esomeprazole; Levofloxacin; Amoxicillin 　　 　　幽门螺杆菌(Hp)感染是消化性溃疡、慢性胃炎的重要致病因素,与胃癌、胃黏膜相关淋巴组织淋巴瘤的发生密切相关。根除Hp对治愈消化性溃疡,预防溃疡复发,缓解胃炎症状,预防癌变均有重要意义。笔者自拟黄龙汤清幽汤治疗Hp感染,获得满意疗效,现报道如下: 　　1 资料与方法 　　1.1病例选择 　　2006年2月~2008年12月就诊于我院中医科的患者。 　　1.2治疗方法 　　治疗组用笔者自拟的黄龙清幽汤加减,主方:黄连9 g,龙胆草6 g,蒲公英15 g,白花蛇舌草15 g,半夏9 g,白芍9 g,甘草6 g。腹胀者加厚朴、佛手,疼痛明显者加郁金、玄胡,嗳气吞酸加代赭石、柿蒂。浓煎取汁200 ml,餐间服用,每日1剂,3个月为1个疗程。对照组用埃索美拉唑20 mg、