手性相转移催化剂及其在不对称催化反应中的应用.PDF

第 18 卷 第 6 期 化　学　进　展 Vol. 18 No. 6 2006 年 6 月 PROGRESS IN CHEMISTRY 　June , 2006 手性相转移催化剂及其在不对称催化 反应中的应用 1 1 2 1 曾莎莎 　唐瑞仁 　Artem Melman 　黄可龙 ( 1 中南大学化学化工学院 　长沙 410083 ; 2. Department of Organic Chemistry , Hebrew University of Jerusalem , Jerusalem 91904 , Israel) 摘 　要 　综述了手性季铵盐、手性冠醚以及其它新型手性相转移催化剂的制备及其在各种不对称相转 移催化反应如烷基化反应、Michael 加成反应、Aldol 反应、Mannich 反应、氧化反应及还原反应中应用的最新 进展。 关键词 　手性相转移催化剂 　不对称催化反应 　手性季铵盐 　手性冠醚 　相转移催化反应 ( ) 中图分类号: O62125 ; O6433 　文献标识码 : A 　文章编号 : 1005281X 2006 Progress of the Chiral Phase Transfer Catalysts and the Applications in Asymmetric Catalytical Reaction 1 1 2 1 Zeng Shasha 　Tang Ruiren 　Artem Melman 　Huang Kelong ( 1. School of Chemistry and Chemical Engineering , Central South University , Changsha 410083 , China ; 2. Department of Organic Chemistry , Hebrew University of Jerusalem , Jerusalem 91904 , Israel) Abstract 　Chiral phase transfer catalysts such as chiral quarternary ammonium salts , chiral crown ethers and their recent advances in the applications in asymmetric catalytic reactions including the alkylation , Michael addition , aldol reaction , Mannich reaction , oxidation and reduction are reviewed in this paper. Key words 　chiral phase transfer catalysts ; asymmetric catalytic reaction ; chiral quarternary ammonium salts ; chiral crown ethers ; chiral phase transfer catalysis