《抗菌素注射液中抗坏血酸最佳剂量的选择研究》-毕业论文.docVIP

PAGE 精品 摘 要 维生素C 是国家基本药物，常用药，稳定性差。金属离子、pH值、抗氧剂、温度等对维生素C 稳定性均有影响。维生素C 的稳定性考察具有十分重要的意义。采用紫外分光光度法测定维生素C 含量，研究维生素C 与左氧氟沙星（Levofloxacin）配伍使用时，维生素C 最佳剂量，研究不同时间、不同温度下维生素C 稳定性。结果表明：维生素C 最大吸收峰在266 nm 处，维生素C 水溶液浓度在2.01~12.06 mg/L范围内具有良好线性关系，线性回归方程A=0.064C+0.0033（r=0.9996，n=5）；维生素C 与左氧氟沙星配伍，混合液无混浊、沉淀现象，为微黄澄明溶液，在不同温度与不同时间均无变化，表明维生素C 与左氧氟沙星配伍稳定性良好。 关键词：维生素C 左氧氟沙星 配伍 稳定性 紫外分光光度法 ABSTRACT Vitamin C is the states basic drugs, Commonly used drugs, poor stability. is a strong reducing agent, easily oxidized.Metal ions, pH, antioxidants, rubber, and temperature on the stability of vitamin C are affected.However, the stability of vitamin C is very important. To UV spectrophotometric determination of vitamin C content, studies of vitamin C combined with the use of levofloxacin, the best dose of vitamin C, at different times, different topical vitamin C temperature stability. The results showed that: Vitamin C maximum absorption peak at 266 nm, the concentration of vitamin C in aqueous solution in 2.01 ~ 12.06 mg / L has a good range of linear relationship, linear regression equation of A = 0.064C +0.0033 (r = 0.9996, n = 5);Vitamin C combined with levofloxacin, the mixture without turbidity, sedimentation phenomenon for clarity Lunatia solution, at different temperatures and different times did not change, indicating that vitamin C and good stability of levofloxacin compatibility. Key words: Vitamin C Levofloxacin Compatibility stability UV spectrophotometry 目 录 TOC \o 1-3 \h \z \u HYPERLINK \l _Toc232950879 摘 要 PAGEREF _Toc232950879 \h I HYPERLINK \l _Toc232950880 ABSTRACT PAGEREF _Toc232950880 \h II HYPERLINK \l _Toc232950881 1 绪 论 PAGEREF _Toc232950881 \h 1 HYPERLINK \l _Toc232950882 1.1 课题的目的和意义 PAGEREF _Toc232950882 \h 1 HYPERLINK \l _Toc232950883 1.2 国内外研究现状 PAGEREF _Toc232950883 \h 1 HYPERLINK \l _Toc232950884 1.2.1 国内研究现状 PAGEREF _Toc232950884 \h 1 HYPERLINK \l _Toc232950885 1.2.2 国外研究现状 PAGEREF _Toc232950885 \h 6 HYPERLINK \l _Toc232950886 1.3 主