NTprBNP、AMA及IL8在婴幼儿先天性心脏病合并重症肺炎诊治中的临床意义.doc

NT-proBNP、ADMA及IL-8在婴幼儿先天性心脏病合并重症 肺炎诊治中的临床意义 咸阳市儿童医院陕西咸阳712000 】目的探讨先天性心脏病合并重症肺炎婴幼儿血清N末端脑钠素原 (NT-ProBNP)、不对称二甲棊精氨酸(ADMA)和白细胞介素-8 (IL-8)联合检测 的临床意义。方法2012年1月至2016年6月收治的先天性心脏病合并重症肺 炎患儿78例为实验组，单纯先心病患儿86例为对照组；在第1天、第3天及第 7天分别检测上述指标并比较两组间不同时间点的差异。结果实验组与对照组 在第1天和第3天NT-ProBNP和ADMA水平差异有统计学意义(P0. 05｝，第7天 两组间差异不显著(P〉0.05＞。实验组与对照组第3天的IL-8水平差异有统计学意 义(P0. 05)，第1天和第7天两组间差异不显著(P〉0. 05＞。结论婴幼儿先天性 心脏病合并重症肺炎急性期心功能损害明显易发生心衰和肺动脉压力增高，具有 较高的死亡率，联合检测NT-PmBNP、ADMA和IL-8有助于精确评价患儿心功能、 肺动脉压力和感染严重程度，科学指导治疗和评估预后的重要血淸学标志物。 关键词】NT-proBNP； ADMA； IL-8；先天性心脏病；重症肺炎 屮图分类号】R548.2 】A 】1001-5213(2016)09-0289-02 The clinical significance of NT-proBNP, ADMA and IL-8 in infants with congenital heart disease complicated by severe pneumonia ZHANG Weihua, LIN Jiane, Shi Feijuan, HAO Lei (Childrenrsquo;s Hospital of Xianyang, Xianyang 712000, Shanxi, China) Abstract: Objective To study the clinical significance of N-terminal pro-brain natriuretic peptide (NT-ProBNP), Asymmetric dimethylarginine (ADMA) and lnterleukin-8 (IL-8) in infants with congenital heart disease (CHD) complicated by severe pneumonia. Methods 78 cases CHD with severe pneumonia in pediatric intensive care unit from January 2012 to June 2016 were selected as experimental group, and 86 CHD cases were selected as control group. Serum NT-ProBNP, ADMA and IL-8 levels were detected and analyzed on the first day, the third day and the seventh day. Results There were significantly difference of NT-ProBNP and ADMA between the experimental group and control group on the first and third day (Ple;0.05), but not significantly difference on the seventh day (P0.05). The levels of IL-8 in experimental group were significantly higher than that in control group on the third day (Ple;0.05), but not higher on the first and seventh day(P0.05). Conclusions The infants with CHD complicated by severe pneumonia had obvious myocardial damage and prone to caused heart failure, increased pulmonary artery pressure, with high mortality. Combined detection of NT-ProBNP,