ys、Lp(a)、胆红素在冠心病患者血清中的表达及意义.docVIP

CysC、Lp(a)、胆红素在冠心病患者血清中的表达及意义 孟庆书 1张言镇 2李玉3 1潍坊医学院(山东潍坊261042) 2潍坊市人民医院 3潍坊市第二人民医 院 】目的探讨血清胱抑素C (cystatinC, CysC)、脂蛋白(a)［ lipoprotein(a), Lp(a)］及胆红素(bilirubin)在冠心病(CHD)患者中表达的意义 及与冠脉病变程度的关系。方法选择CHD患者180例，按临床类型分为稳定型 心绞痛(SAP)组50例、不稳定型心绞痛(UAP)组90例、心肌梗死(AMI)组 40例，按冠脉造影结果分为单支病变组74例、双支病变组56例、三支病变组 50例，另选60例健康者作为对照组。定量测定所有入选者的血清CysC、LP(a) 及胆红素水平。结果血清CysC水平在SAP组、UAP组及AMI组显著低于正常 对照组(Plt;0.05),且随着冠脉病变支数的增加而逐渐下降(Plt;0.05)；血清 LP (a)水平在SAP组、UAP组及AMI组高于对照组(Plt;0.05), UAP组、AMI 组均高于SAP组(Plt;0.05)；血清LP (a)水平与不同冠脉病变支数间差异有统 计学意义，三支病变组、双支病变组和单支病变组均高于正常对照组(Plt;0.05), 1.三支病变组高于单支病变组(Plt;0.05)；患者血清总胆红素、间接胆红素水 平在SAP组、UAP组及AMI组均低于正常对照组(Plt;0.05),三支病变组、双 支病变组和单支病变组均低于正常对照组(Plt;0.05)；患者血清直接胆红素水 平在各组间无明显差异(Pgt;0.05)。结论冠心病患者血清CysC、胆红素水平 下降，Lp⑻水平升高，其浓度水平能够反映冠脉病变的严重程度，可作为临床观 察和评定冠状动脉病变发展的指标。 关键词】冠心病CysCLp⑻胆红素动脉粥样硬化 ［ ］R969 ［ ］A ［ ］1810 — 5734(2011)12-05-03 The expression and Significance of CysC, Lp(a), bilirubin in Serum of Patients with Coronary Heart Disease ABSTRACT】 ObjectiveTo explore cystatin C, lipoprotein(a) and bilirubin serum expression significance in patients with coronary atherosclerotic heart disease(CHD), and the relationship with coronary artery stenosis.MethodsThe 180 CHD patients were divided into stable angina pectoris (SAP) group (50 case), unstable angina pectoris (UAP) group (90 case) and acute myocardial infarction (AMI)group (40 case). The patients who underwent coronary radiography were subdivided as group with one-vessel lesion, group with two-vessel lesion, group with three-vessel lesion. The control group was 60 healthy individuals. The serum levels of cystatin C, lipoprotein(a) and bilirubin were quantitative detected for all subjects.ResultsCysC in CHD patients were obviously lower than that in control group (Plt;0.05), and the CysC levels decreased in four subgroups (according control group, one-vessel lesion, two-vessel lesion, three-vessel lesion order) (Plt;0.05). Lp(a) in CHD group was obviously higher than that in control group (Plt;0.05), UAP group and AMI