性病门诊就诊者支原体感染状况及耐药剖析.docVIP

性病门诊就诊者支原体感染状况及耐药剖析 　　【第一作者简介】邱振（1976-），男，主管药师，主要从事药学与医院制剂研究工作。 　　DOI:10.3969/j.issn.1672-1993.2014.07.025 　　【摘要】目的:了解我院性病门诊解脲支原体（Uu）、人型支原体（Mh）的感染状况和耐药情况，指导临床合理选用抗菌药物。方法:对性病门诊2011年至2013年疑似非淋菌尿道炎（NGU）患者的实验室报告进行回顾性调查，对检验数据进行统计分析。结果:3年中，5526例患者中，Uu感染1979例(35??81%)，Mh感染382例(6??91%)，混合感染214例（3??87%）。解脲支原体药敏趋势显示，交沙霉素、米诺环素、多西环素、克拉霉素有较高的抑菌能力，环丙沙星耐药明显。人型支原体药敏显示，交沙霉素、米诺霉素、多西霉素依然有效，大环内酯类和喹诺酮类出现较强的耐药。结论:我院性病门诊患者支原体属感染率高，可选用抗菌药品种少，要引起医院的重视，应在药敏结果指导下合理选药，减缓耐药菌株的产生。 　　【关键词】解脲支原体；人型支原体；感染状况；药敏 　　Mycoplasma infection status and drug resistance of the patients in the STD clinicQIU Zhen1, LI Shiyuan2, QIN Shanlie3, ZHU Bangyong2. 1. Drug and Equipment Section，Guangxi Zhuang Autonomous Region Dermatosis Hospital, Nanning 530003, China; 2.Department of Laboratory, Guangxi Zhuang Autonomous Region Dermatosis Hospital, Nanning 530003, China; 3. Social Epidemic Prevention Department, Guangxi Zhuang Autonomous Region Dermatosis Hospital, Nanning 530003, China 　　【Abstract】Objectives: To investigate the infection status and drug resistance situation of ureaplasma urealyticum (Uu) and mycoplasma hominis (Mh) in STD clinic，to guide clinical rational use of antimicrobial drug. Methods: A retrospective review of the laboratory reports of patients suspected of non-gonococcal urethritis(NGU) in the STD clinics from 2011 to 2013was carried out，and a statistical analysis was conducted to analyze test data. Results: Of all the 5526 patients in the three years, 1979 cases (35.81%), 382 cases (6.91%) and 214 cases (3.87%) suffered from Uu infection, Mh infection and mixed infection respectively. Uu-drug sensitive test showed that josamycin, minocycline, doxycycline and clarithromycin were of higher antibacterial ability and ciprofloxacin was apparently drug-resistant. Mh-drug sensitive test showed that josamycin, minocycline and doxycycline were still effective, and macrolide and quinolones were of strong drug-resistance. Conclusion: In STD clinic, patients are of high mycoplasma infection rates