- 28
- 0
- 约5.5万字
- 约 59页
- 2018-11-24 发布于江苏
- 举报
Results:Todeterminethe mesalazinecontained
optimalparameters pills:
theMCCaccountedfor10%ofthe ofHPMCconcentration
prescriptionproportion
the of1000
of extrusion r/min,
6%, speed30r/min,spheronizationspeed
of4min. Mesalazine
the time
spheronization Preparedmethod:f’rescription:
60mesh setthewet
bulk accessories
drugsgrinding,mixing through sieVe,
∥, mixed an
machinemixed ofsoftmaterial,5min,adding
granulation system
amountofwater ofsoftmaterial30r/min
● appropriate granulationproceeds
withinto rounded
afterextrusionhome Machine 1000r/min 4min,
Rounding
into the
thethrownintothe rounded
during starch,it pellets.RemoVepellets
and fluidizedbed the18—28
50℃by drying25min.Screening,selectpurpose
ofbetter ofmore
of Theobtained Oftheroundness
pellets. pellets yield
than85%.Determinethe of The
weightgain12%,
coatingprocess:coating
of RLand RS
ratio
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