美沙拉嗪控释胶囊处方工艺及质量标准-研究.pdfVIP

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美沙拉嗪控释胶囊处方工艺及质量标准-研究.pdf

Results:Todeterminethe mesalazinecontained optimalparameters pills: theMCCaccountedfor10%ofthe ofHPMCconcentration prescriptionproportion the of1000 of extrusion r/min, 6%, speed30r/min,spheronizationspeed of4min. Mesalazine the time spheronization Preparedmethod:f’rescription: 60mesh setthewet bulk accessories drugsgrinding,mixing through sieVe, ∥, mixed an machinemixed ofsoftmaterial,5min,adding granulation system amountofwater ofsoftmaterial30r/min ● appropriate granulationproceeds withinto rounded afterextrusionhome Machine 1000r/min 4min, Rounding into the thethrownintothe rounded during starch,it pellets.RemoVepellets and fluidizedbed the18—28 50℃by drying25min.Screening,selectpurpose ofbetter ofmore of Theobtained Oftheroundness pellets. pellets yield than85%.Determinethe of The weightgain12%, coatingprocess:coating of RLand RS ratio

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