老年高血压患者同型半胱氨酸升高伴血脂异常剖析.docVIP

老年高血压患者同型半胱氨酸升高伴血脂异常剖析 　　摘 要 目的：研究老年高血压伴同型半胱氨酸（Hcy）患者的血脂情况，探讨Hcy对动脉粥样硬化的可能影响。方法：收集中心2013年2月至2014年2月间诊治的老年高血压患者80例为研究对象，根据Hcy数值分为H型高血压组和非H型高血压组，检测并比较两组患者的Hcy及血脂水平。结果：H型高血压患者较多，为48例（60%），非H型高血压患者为32例（40%）。H型高血压组的低密度胆固醇水平明显高于非H型高血压组，而高密度胆固醇及载脂蛋白A明显低于非H型高血压组，差异均有统计学意义（P0.05）。结论：老年高血压患者较多伴有Hcy升高，同时预示其血脂异常，与动脉粥样硬化病变的发生可能相关。 　　关键词 高血压 同型半胱氨酸 血脂 老年 　　中图分类号：R544.1/R541.4 文献标识码：A 文章编号：1006-1533（2015）02-0033-03 　　Analysis of the homocysteine with dyslipidemia of the elderly patients with hypertension 　　ZHU Jie 　　（Wujiaochang Town Community Health Service Center of Yangpu District， Shanghai 200433， China） 　　ABSTRACT Objective： To study the blood lipid of the elderly patients with hypertension accompanied by homocysteine （Hcy） and to explore the possible impact of Hcy on the atherosclerosis. Methods： Eighty cases of the elderly patients with hypertension who were diagnosed and treated in this center from Feb. 2013 to Feb. 2014 were selected as the research subjects， and divided into an H type hypertension group and a non-H type hypertension group according to the Hcy values， and their levels of Hcy and blood lipid were detected and compared. Results： There were more H type hypertensive patients with 48 cases （60%）， and non-H ones， 32 （40%）. The LDL level of the patients in the H type hypertension group was obviously higher than that in the non-H type hypertension group. The HDL and lipoprotein in the H type hypertension group was obviously lower than those in the non-H hypertension group， and their difference had the statistical significance （P0.05）. Conclusion： The elderly patients with hypertension are commonly accompanied with the elevated Hcy level which at the same time indicates the blood lipid abnormality， and is closely related to the occurrence of atherosclerotic lesions. 　　KEY WORDS hypertension； homocysteine； blood lipid； elderly people 　　同型半胱氨酸（Hcy）是一种含硫氨基酸，主要是半胱氨酸和蛋氨酸代谢的中间产物[1]。目前认为Hcy可以作为老年人心脑血管疾病的一项独立的危险因素，并逐渐受到重视。相关研究显示，老年人Hcy型（H型）高血压较非H型高血压多见，H型高血压患者因动