芳基修饰的藤黄酸衍生物的合成及抗肿瘤活性研究-药理学专业论文.docx

万方数据 万方数据 目录 中英文词汇对照表·········································· 1 芳基修饰的藤黄酸衍生物的合成及抗肿瘤活性研究······················2 中文摘要····························································2 英文摘要···························································4 第一章 研究背景················································6 1.1 肿瘤的危害与治疗················································6 1.2 藤黄及藤黄酸的概况···································· 6 1.2.1 藤黄酸的理化性质··············································7 1.2.2 藤黄酸剂型及剂型改良··········································7 1.3 藤黄酸的抗肿瘤作用机制···································· 7 1.3.1 诱导肿瘤细胞凋亡··············································8 1.3.2 抑制肿瘤细胞增殖··············································11 1.3.3 抑制肿瘤细胞迁移·············································13 1.3.4 逆转多药耐药性·············································14 1.3.5 结语············································· 14 1.4 藤黄酸的构效关系及其结构改造···································14 1.4.1 藤黄酸类似物的合成及其构效关系·······························15 1.4.2 藤黄酸 C-6 位的结构改造 16 1.4.3 藤黄酸 C-9、10 位的结构改造 16 1.4.4 藤黄酸 C-32、33 位的结构改造 17 1.4.5 藤黄酸 C-35 位的结构改造 17 1.4.6 藤黄酸 C-37、38 位的结构改造 17 1.4.7 藤黄酸 C-40 位的结构改造 18 1.4.8 转位藤黄酸的改造········································18 1.4.9 藤黄酸 C-30 位的结构改造 18 1.5 本课题研究的意义与前景········································19 第二章 设计思想········································ 21 2.1 藤黄酸苯氧基醇酯的设计合成····································21 2.2 藤黄酸芳杂环氧基醇酯的设计合成·······························23 2.3 藤黄酸苯甲（乙）酰氨基醇酯的设计合成······························25 2.4 藤黄酸衍生物抗肿瘤活性研究································ 26 2.5 藤黄酸衍生物的水溶性研究····························· 27 第三章 实验部分···················