潮汕地区健康体检人群非酒精性脂肪肝流行病学调查-临床医学(感染科)专业论文.docx

Abstract 0bjective To investigate the prevalence and risk factors of Non-alcoholic fatty liver disease (NAFLD) in health clinical examination population in Chaoshan region, and to explore the relationship of alanine aminotransferase and metabolic syndrome and its components, in order to provide more theory for Non-alcoholic fatty liver disease’s treament. Method The survey was conducted among 1221 adults from October 2010 to January 2011 in medical examination center in the Fisrt Affiliated Hospital of Medical College of Shantou University. The participants had patient history, clinical examination, anthropometry, laboratory tests and routine liver ultrasonography. Use case-control study, patients were divided into two groups(NAFLD and non-NAFLD) and compared their demographic characteristics, biochemical, metabolic syndrome and its components. Then, the patients with NAFLD were divided into two groups including elevated serum ALT and normal serum ALT. Compared the two groups in demographic characteristics, biochemical, metabolic syndrome and its components. Using binary logistic regression analysis risk factors of non-alcoholic fatty liver patients with high ALT levels. Result 1. Of 1221 adults took part in the survey, 854 were males and 367 were females. The mean age of the participants was 46.40±14.67 years and ranged from 18~95 years. The age-sex-adjuste prevaence of NAFLD in all participants was 29.1%. The age-adjusted prevalence of NAFLD in men (33.9%) was significantly higher than that in women (18%)(P=0.001). The prevalence of NAFLD was increased with aging in males and in females(tendency,P0.001). 2.The body mass index(BMI), waist circumference(WC), waist hip ratio(WHR), blood pressure, fasting blood glucose level(FBG), triglyceride(TG), total cholesterol(TC), low-density lipoprotein cholesterol(LDL-C), uric acid(UA), alanine aminotransferase level(ALT), and the incidence of obesity, hyperuricemia, hypertension, dyslipidemia, abnormal hepatic function in N