肠道益生菌对2型糖尿病合并代谢综合征患者的临床疗效观察.docVIP

肠道益生菌对2型糖尿病合并代谢综合征患者的临床疗效观察 目的：观察常规治疗联合培菲康对2型 糖尿病合并代谢综合征患者血糖、血脂、血压、体重 控制的临床疗效。方法：收集2015年4月1日一2015 年6月30日期间在甘泉街道社区卫生服务中心门诊 就诊的2型糖尿病合并代谢综合征患者100例，采用 1:1配对分组(年龄、性别、基础疾病)法分为对照 组和试验组各50例，对照组给予常规降糖、降脂、降 压治疗，试验组加用培菲康840 mg，2次/d 口服，疗 程为6周。比较治疗前后两组血糖、血脂、血压、体 重变化以及停药后6周的疗效差异。结果：6周后试 验组与对照组相比血糖、血压、血脂、体质均未见明 显差异(P0.05)；然而停药6周后，两组空腹血糖、 餐后2 h血糖、总胆固醇数值下降具有统计学意义(P 关键词益生菌代谢综合征2型糖尿病 :R282.71; R589.2 :B文 章编号:1006-1533 (2016) 19-0017-03 Clinical effect of probiotics on type 2 diabetes patients complicated with metabolic syndrome ZHU Weifang (The Ganquan Community Health Service Center of Putuo District，Shanghai 200065，China) ABSTRACT Objective： To observe the clinical effect of conventional therapy combined with Bifico on glucose，blood lipid, blood pressure and weight control in patients with type 2 diabetes complicated with metabolic syndrome. Methods： One hundred cases of type 2 diabetes patients were collected and randomly divided into a control group and an experimental group with 50 cases each. The control group was treated with conventional hypoglycemic， lipid lowering and antihypertensive therapy while the experimental group was additionally treated with 840 mg of oral Bifico twice a day besides the conventional therapy for 6 weeks. Blood glucose， blood lipid, blood pressure and body weight were compared before and after treatment between two groups. Results： After 6 weeks， there were no significant differences in the levels of blood glucose， blood lipid and blood pressure and physique between two groups (P0.05). However，the decrease of the levels of fasting blood glucose and postprandial blood glucose and the total cholesterol values showed statistical significance between two groups after the treatment was discontinued for 6 weeks （P15%，患者 超过2亿人［1］。常用的治疗手段为降糖、降压、降脂, 同时，越来越多的证据表明，肠道菌群与肥胖、胰岛 素抵抗等代谢性疾病的发生密切相关，可能成为预防 和治疗肥胖症的新靶点［2］。本研究通过观察与比较在 常规治疗下联合益生菌治疗后对代谢综合征的疗效， 旨在为临床治疗代谢综合征提供新的思路和方法。 1资料与方法 1.1研究对象 选取2015年4月1日一6月30日在甘泉街道社 区卫生服务中心门诊就诊的糖尿病合并代谢综合征患 者100例，其中男38例，女62例，平均年龄68岁。