膀胱肿瘤预后相关的分子指标的研究进展.docVIP

膀胱肿瘤预后相关的分子指标的研究进展 ［ ］膀胱癌是我国泌尿外科临床上最常见的肿瘤之一,分为非肌 层浸润性膀胱癌及肌层浸润性膀胱癌，是一种直接威胁患者生存的疾 病。膀胱肿瘤以其高复发率为主要表现，是目前闲扰临床医生的一个 问题，不仅增加患者的治疗费用同时也大大降低了患者的生活质量。 随着医学研究的迅速发展，对于肿瘤的研究逐渐深入到分子水平，发 现某些分子指标对于肿瘤的病理及临床分期有指导意义，因此对于高 复发率的膀胱肿瘤进行分子指标的研究，对于指导膀胱肿瘤患者的预 后及提高患者的生活质量有重要指导意义。本文将就膀胱肿瘤新的分 子指标的研究进展进行综述。 和著作权归原 所有， 匕 ［关键词］膀胱肿瘤；N-钙黏附素蛋白；干性相关长链非编码RNA; CD8+T细胞；预后 ［ ］R737. 14 ［ ］A ［ ］1673-9701 (2017) 03-0161-04 Research progress of molecular indices related to the prognosis of bladder tumor XIAO Yil ZHANG Yangang2 (RIO Qiangl 1.Shanxi Medical University, Taiyuan 030001， China； 2.Department of Urinary Surgery , Shanxi DaYi Hosptial Affiliated to Shanxi Medical University, Taiyuan 030001, China [Abstract] Bladder cancer is one of the most commonly seen tumors clinically in the department of urinary surgery in China. It is divided into non-muscular invasive bladder cancer and muscular invasive bladder cancer, which is a disease with a direct threat to human life. The bladder tumor is mainly characterized by its high recurrence rate, which is a problem faced with the clinical physicians currently. The tumor with high recurrence not only increases patients ? treatment expenses, but also greatly reduced their life quality. With the rapid development of medical research, the tumor research is gradually deepening into the molecular level, and discovery of some molecular indices plays a guiding significance in tumor’s pathology and clinical staging. Therefore, the research on the molecular indices in the bladder tumor with high recurrence plays an important guiding signifiance in guiding the prognosis in the patients with bladder tumor and improving their life quality. This artical will review on the research progress of new molecular indices of bladder tumor. ［Key words］ Bladder tumor； N-cadherin; IncRNAs； CD8+T cell； Prognosis 膀胱癌是泌尿生殖系最常？的恶性肿瘤，在美国男性恶性肿瘤中占 第4位，女性恶性肿瘤中占第7位，美国2010年新发膀胱癌患者70 530 例，其中14 680例死亡［1］。75%?80%的患者最初诊断为非肌层浸润 性膀胱癌(non-muscle invasive bladder cancer, NMIBC),而 50%? 60%的NMICB患