长链非编码RNA与心血管疾病的关系-中国细胞生物学学报.PDF

网络出版时间：2015-10-21 14:51:51 网络出版地址：/kcms/detail/31.2035.Q1451.004.html 中国细胞生物学学报 Chinese Journal of Cell Biology 2015, 37(10): DOI: 10.11844/cj cb.2015.10.0160 长链非编码RNA与心血管疾病的关系 * * 钱海霞 季林丹 徐 进 (宁波大学医学院, 宁波3152 11) 摘要 心血管疾病是当今全球人群的首要死因, 也是引起期望寿命损失最主要的疾病。大 量研究用流行病学、病理生理学、分子生物学等方法揭示该类疾病的发病机制，并取得了重大进展。 近年来, 随着遗传学和生物信息技术的飞速发展, 越来越多的研究发现长链非编码RNA(long non- coding RNA, lncRNA)与心血管疾病的发生、发展、诊断和治疗密切相关。该文就lncRNA与心血 管疾病的关系作一综述, 以期帮助读者了解lncRNA在心血管疾病发生发展中的作用。 关键词 长链非编码RNA; 心血管疾病; 表观遗传学; 发病机制 Relationship Between of Long Non-coding RNA and Cardiovascular Disease Qian Haixia, Ji Lindan*, Xu Jin* (Ningbo University School of Medicine, Ningbo 315211, China) Abstract Cardiovascular disease is the leading cause of human death in the world, which is also the major cause for loss of life expectancy. A great number of studies have been carried out to delineate the underlying mechanisms through epidemiological, pathophysiological or molecular methods, and have made significant progress. With the rapid development of genetic and bioinformatical technologies, recent studies have found that the long non-coding RNA (lncRNA) is closely associated with the development, prognosis, diagnosis and treatment of cardiovascular disease. This review summarizes the current state of knowledge about the association between lncRNA and cardiovascular disease,