腹腔镜术后联合曲普瑞林治疗子宫内膜异位症的临床疗效-妇产科学专业论文.docxVIP

新疆医科大学硕士学位论文 新疆医科大学硕士学位论文 1 1 腹腔镜术后联合曲普瑞林治疗子宫内膜异位症 的临床疗效 研究生：张静 导师：艾星子·艾里副教授 摘 要 目的：探讨腹腔镜保守性手术后联合曲普瑞林治疗子宫内膜异位症的临床疗效。 方法：将 100 例子宫内膜异位症患者行腹腔镜保守性手术后随机分成 3 组：A 组 42 例, 每 4 周皮下注射曲普瑞林（3.75mg，3 个月）；B 组 36 例, 每 4 周皮下注射曲 普瑞林（3.75mg，6 个月）；C 组：22 例，为对照组，术后不用任何药物，共随访 2 年,比较三组的疗效、复发率、复发时间、临床妊娠率及疼痛症状视觉模拟评分 （VAS）。结果：共有 3 例未完成随访(A 组 1 例,B 组 2 例) 。B 组患者的临床疗效 优于 A 组和 C 组，差异有统计学意义(P 均0.017）； A 组、B 组、C 组的复发率 分别为 4.6%、5.9%、36.4%，A 组与 B 组和 C 组分别比较，差异均无统计学意义(P 0. 017)，但 B 组的复发率明显低于 C 组，差异有统计学意义（P=0.004）。A 组患 者的临床妊娠率（47.6%）高于 B 组（30.8%）和 C 组（25%），但三组比较，差异无 统计学意义（P 0.05）；B 组患者治疗后 VAS 评分较 A 组与 C 组患者显著下降，差 异有统计学意义（P 0.001）。结论：腹腔镜保守性手术后联合曲普瑞林（3.75mg， 6 个月）治疗子宫内膜异位症, 可以降低疾病复发率, 改善临床症状，是一种有效的 临床治疗方法。 关键词：子宫内膜异位症 腹腔镜保守性手术 曲普瑞林 Clinical efficacy of Triptorel combined with laparoscopic surgery for endometriosis Postgraduate:ZhangJing Supervisor:AssociateProfessor AiXingZi·AiLi Abstract Objective：To analyze clinical effect of Triptorel combined with conservative laparoscopic surgery for endometriosis. Methods ： One hundred patients with endometriosis who underwent conservative laparoscopic surgery were randomly assigned into three groups : A group (n=42) , patients treated with Triptorel (3.75mg/4w) for three months;B group (n=36), patients treated with Triptorel (3.75mg/4w) for six months;C group (n=22),control group, patients had not taken any drugs. All patients were followed up after two years, effective rate, recurrence rate, median recurrence time, clinical pregnancy rate and visual analog scale (VAS) in the two groups were observed and compared. Results：3 cases in all patients lost follow-up(1 case in A group, 2 cases in B group). The clinical efficacy in B group was higher than A group and C group, the differences did reach statistical significance (P 0 .017); the recurrence rate in A group,B group and C group was 4.6%, 5.9%, 36.4% respectively. the recurrence rate in A group was lower than C group, the differences did not reach statistical significance (P 0. 017), the recurrence rate in