氟尿嘧啶缓释植入剂治疗卵巢恶性肿瘤的近期疗效观察-妇产科专业论文.docx

— — PAGE 10— 摘 要 氟尿嘧啶缓释植入剂治疗卵巢恶性肿瘤的 近期疗效观察 研究生：张树丽 导师：丁岩教授 摘 要 目的：观察氟尿嘧啶缓释植入剂治疗卵巢恶性肿瘤的安全性及近期疗效。方法： 将 43 例卵巢恶性肿瘤患者分为治疗组（20 例）与对照组（23 例）。对照组常规手术 并术后 2 周常规化疗，治疗组加用术中即时植入氟尿嘧啶缓释植入剂，术后 4 周开 始化疗。比较两组间手术前后的血常规、肝肾功能，术后及化疗中胃肠道反应、刀 口愈合、住院天数等情况；随访 6-12 月了解复发情况。结果：1.两组间手术前后血 常规比较无显著差异(P0.05)，两组治疗后肝肾功能指标较手术前升高（P0.05），但 两组间比较无差异(P0.05)。2.术后及化疗过程中两组间胃肠道反应比较无显著性差 异(P0.05)。3.因样本量少，随访观察时间较短，目前尚不能说明两组间近期复发有 差别。结论：氟尿嘧啶缓释植入剂局部化疗可以提高局部药物浓度，延长药物与肿 瘤细胞的作用时间，无明显不良反应，是一种较为安全的局部化疗方法。但其对复 发率及远期生存率的影响尚需进一步研究。 关键词：卵巢恶性肿瘤；氟尿嘧啶缓释植入剂 新疆医科大学医学硕士学位论文 The Short-term Therapeutic Observation about the sustained-release fluorouracil for implant for Malignant Tumors of Ovary Postgraduate: Zhang Shu Li Supervisor: Ding Yan Professor Abstract Objective: To observe the short-term therapeutic observation about the sustained-release fluorouracil for implant for malignant tumors of ovary. Methods: 43 patients with malignant tumors of ovary, were divided into controlled group and sustained-release fluorouracil group. The tumor was surgically removed and sustained release fluorouracil were implanted multiple point during operation in the tumor cavity to observe the incidence of wound infection, anastomosis leakageand wound infection and days of in-hospital. WBC, RBC,Hb, ALT and Cr were also observed. Follow up 6-12 months to get the message of recidivation. Results: The difference of side effects and postoperative complications between controlled group and sustained-release fluorouracil group was not obviously, ALT and Cr were different before and after operation, but the difference of two group was not obviously. The different of recidivation between controlled group and sustained-release fluorouracil group was not obviously. Conclusion: The method of intra-operative implanted sustained-release fluorouracil is safe, and it might become a new promising method to prevent postoperative local recurrence. Key Words :Malignant Tumors of Ovary; Sustained-release Fluorouracil for Implant 学位论文独创性说明 本人所呈交的学位论文是在我导师的指导下进行的研