福建省女性乳腺癌危险因素的单中心病例对照研究-肿瘤学专业论文.docxVIP

万方数据 万方数据 目录 一 、中文摘要 ································ ······················ （ 4 ） 二 、英文摘 要 ································ ······················ （ 5 ） 三 、英文缩略词 对照 表 ································ ··········· （ 6 ） 四、正文 ································ ···························· （ 7 ） 前言 ································ ······························ （ 7 ） 1 、材料和方法 ································ ················· （ 8 ） 2 、结果 ································ ························ （ 1 0 ） 3 、讨论 ································ ························ （ 1 8 ） 4 、结论 ································ ························ （ 23 ） 5 、参考文献 ································ ··················· （ 24 ） 五、致谢 ································ ··························· （ 2 8 ） 六、综述 ································ ··························· （ 29 ） 3 福建省女性乳腺癌危险因素的单中心病例对照研究 中文摘要 目的：通过流行病学调查分析，探讨影响福建女性乳腺癌发生的相关危险因素， 为乳腺癌的预防提供一定的参考依据。 方法：本研究采用单中心病例对照研究方法，研究对象来源于福建医科大学附属 协和医院乳腺外科和体检中心，包括病例组 975 例及对照组 1091 例。通过问卷 调查，收集乳腺癌患者及健康体检者的相关危险因素情况，应用 SPSS17.0 统计 软件进行乳腺癌相关危险因素的单因素和多因素非条件 Logistic 回归分析。 结果：单因素分析和多因素分析结果显示：初潮年龄≤12 岁（OR=1.619，95％ CI： 1.073～2.444)、乳腺癌家族史(OR=2.357，95％ CI：1.535～3.621)、饮酒史 (OR=6.376，95％ CI：1.781～22.822) 为福建女性乳腺癌的危险因素。 结论：初潮年龄早（≤12 岁）、家族史、饮酒史为福建女性乳腺癌的危险因素。 关键词：乳腺癌；危险因素；病例对照研究 4 Single Centre Case-Control Study on breast cancer risk factors in Fujian Province Abstract Objective A Single Centre-Case Control Study was conducted to explore risk factors of female breast cancer in Fujian Province. Methods A Single Centre-Case Control study on 975 breast cancer patients and 1091 controls was conducted in Fujian Medical University Union Hospital ． Conditional Univariate and multivariate logistic regression was applied to analyze the association between risk factors and breast cancer． Results Univariate and multivariate logistic regression analysis indicated that age of menarche≤12 （OR=1.619，95％ CI：1.073～2.444)、 family history of breast cancer(OR=2.357，95％ CI：1.5